120 CAPS Product No. 00670

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Peanut and Tree Nut Free Nut Free
Dairy Free Dairy Free
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Current lifestyles can be stressful and the standard American diet does not always provide needed nutrients. MetaCalm® provides the amino acid building blocks and the necessary vitamin and mineral cofactors to help the body’s synthesis of both mood enhancing and calming neurotransmitters. Amino acids like L-theanine can help induce an alert state of relaxation without drowsiness, while GABA and glycine can soothe the effects of excitatory neurotransmitters. 5-HTP is a building block of serotonin, an important mood and stress regulating neurotransmitter. MetaCalm® is a full spectrum nutritional product to encourage relaxation of the central and peripheral nervous system. *

  • Provides B vitamin cofactors and amino acids for neurotransmitter synthesis*
  • Calms without sedating*
  • Supports both calming and mood balancing neurotransmitter pathways*


*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.



Product Code: 00670          Capsules per Bottle: 120    


Each serving of 3 size 00 vegetarian cellulose capsules contains:

Vitamin C (as Ascorbic Acid)

40 mg

Vitamin B6 (Pyridoxal 5 Phosphate)

25 mg

Folate (200 mcg folate as L-5-Methylfolate, glucosamine salt)

333 mcg DFE

Vitamin B12 (as Methylcobalamin)

30 mcg

Magnesium (as Magnesium Glycinate)

300 mg

Zinc (as Zinc Glycinate)

10 mg

Selenium (as L-Selenomethionine)

70 mcg

Proprietary Blend:  GABA (Gamma Aminobutyric Acid), Taurine, Inositol, 5-HTP (5-Hydroxytryptophan), L-Theanine (Suntheanine®)

900 mg

Other ingredients: L-Leucine.


Description: MetaCalm® is a full spectrum nutritional product to encourage relaxation of the central and peripheral nervous systems.


Uses: Stress is an increasing factor in modern life. Neurotransmitters play an important role in the regulation of mood, anxiety, and reaction to stress (1). MetaCalm® provides the amino acid building blocks and the necessary vitamin and mineral co-factors to support production of both mood-enhancing and calming neurotransmitters.


Vitamin C, the most important water-soluble antioxidant in the body, is a cofactor in the biosynthesis of the catecholamine neurotransmitters, epinephrine, norepinephrine, and dopamine.


 MetaCalm® contains the biologically active forms of the B-vitamin cofactors needed for neurotransmitter synthesis: L-methylfolate, pyridoxal 5 phosphate (B-6), and methylcobalamin (B-12). The minerals magnesium, zinc and selenium are involved in many enzymatic reactions including neurotransmitter synthesis and breakdown. Low levels of these minerals have been linked to anxiety and mood disorders, and supplementation can have a beneficial effect (2,3,4).


GABA is an inhibitory neurotransmitter that may reduce stress and anxiety, promote relaxation and improve sleep. Orally administered GABA has been shown to increase alpha waves and decrease beta waves in the brain- an indicator of relaxation (5)


Taurine can cross the blood-brain barrier where it acts as an inhibitory neurotransmitter in the central nervous system, calming over-stimulated neurons and protecting against glutamate toxicity (6).


Inositol is a second-messenger precursor, and this activity is related to activation of serotonin receptors. Studies have shown inositol to be effective for panic disorder (7) and to improve anxiety and stress scale scores (8).


5-HTP is an immediate precursor to serotonin, an important neurotransmitter that plays a role in mood, sleep, anxiety, appetite, pain sensation, and gut health. Clinical trials indicate that 5-HTP provides support for healthy sleep, normal moods and emotional well-being (9).


Able to cross blood-brain barrier, L-theanine increases levels of GABA, serotonin, dopamine and glycine in various regions of the brain, promoting relaxation without drowsiness. L-theanine has been shown to promote alpha-wave activity in the brain, a sign of relaxation (10).


Source Materials: Vitamin C (ascorbic acid): corn sorbitol. Pyridoxal 5 phosphate, L-methylfolate, GABA, taurine, inositol, glycine and methionine (for mineral chelates): chemical synthesis. Glucosamine for L-methylfolate, glucosamine salt: corn fermentation. Methylcobalamin: fermentation. Minerals are mined. L-theanine: enzymatic synthesis. Cellulose for capsules is derived from softwood tree pulp. All ingredients are vegan and non-GMO.


Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.


Recommendations: Use as directed by a healthcare professional.


Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.



  1. Durant C, Christmas D, Nutt D. The pharmacology of anxiety. Curr Top Behav Neurosci. 2010;2:303-30.
  2. Cope EC, Levenson CW. Role of zinc in the development and treatment of mood disorders. Curr Opin Clin Nutr Metab Care. 2010 Nov;13(6):685-9.
  3. Boyle, NB, Lawton CL, Dye L. The effects of magnesium supplementation on subjective anxiety. Magnes Res. 2016 Mar 1;29(3):120-125.
  4. Benton D, Cook R. The impact of selenium supplementation on mood. Biol Psychiatry. 1991 Jun 1;29(11):1092-8.
  5. Abdou AM, et. al; Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors. 2006;26(3):201-8.
  6. Wu J, Prentice H. Role of taurine in the central nervous system. Journal of Biomedical Science 2010, 17(Suppl 1).
  7. Benjamin J, Levine J, et al. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatry. 1995 Jul;152(7):1084-6.
  8. Jamilian H, Jamilian M, et al. Comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. J Psychosom Obstet Gynaecol. 2017 Oct 5:1-8.
  9. Birdsall T. 5-hydroxytryptophan: a clinically effective serotonin precursor. Altern Med Rev. 1998;3(40:271-280.
  10. Nobre A, Rao A, Owen G. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr 2008;17(S1):167-168.




These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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  • Eleanor Gibbs

    2018-11-15 12:22 pm


    This really works .

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