60 CAPS | 500 MG Product No. 00705

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Egg Free Egg Free
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Peanut and Tree Nut Free Nut Free
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GluDaZyme™ is a comprehensive digestive enzyme that helps to digest gluten, casein, complex carbohydrates, sugars, lactose, and fats. GluDaZyme™ contains a proprietary dipeptidyl peptidase IV (DPP-IV) enzyme blend. It is specially formulated to help support healthy digestion processes and normal response to gluten and casein peptides. GluDaZyme™ also aids in normal digestion for severe food sensitivities and helps mitigate repercussions of cross-contact. *

  • Optimizes digestion of protein, fats, and carbohydrates*
  • Enhances nutrient availability*
  • May ease impact of common food sensitivities*
  • Created specifically to help those sensitive to gluten and dairy*


* These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.



Product Code: 00705           Capsules per Bottle: 60

Each size 00 vegetarian cellulose capsules contains:


Proprietary Enzyme Blend:

Dipeptidyl Peptidase (DPP-IV) (Protease I, Protease II, Protease III, Protease IV, Protease V), Amylase I, Amylase II, Glucoamylase, Cellulase, Hemicellulase, Alpha Galactosidase, Xylanase, Lactase, and Lipase.

500 mg

Other Ingredients: tapioca maltodextrin.


What is GluDaZyme™?

GluDaZyme™ contains a proprietary dipeptidyl peptidase IV (DPP-IV) enzyme blend that aids in the breakdown of gluten, casein, complex carbohydrates, sugars, lactose, and fats. Aside from supporting healthy digestion processes and normal response to gluten and casein peptides, GluDaZyme™ also aids in normal digestion for those with severe food sensitivities and can help to mitigate repercussions of cross-contact.


How does GluDaZyme™ Work?

The process of eating any food will provoke the secretion of multiple gastrointestinal hormones involved in the regulation of gut motility, secretion of gastric acid and pancreatic enzymes, gallbladder contraction, and nutrient absorption [1]. Some conditions, such as dairy and gluten intolerance, are characterized by insufficient production of particular digestive enzymes, such as lactase or DPP-IV. Supplementing some of these enzymes may optimize digestion by breaking down food particles the food-sensitive body is normally under-equipped to do, thereby enhancing nutrient availability.  

Dipeptidyl peptidase IV (DPP-IV) is a unique multifunctional type II transmembrane glycoprotein that acts as a receptor, binding protein, and proteolytic enzyme. DPP-IV is widely distributed in mammalian tissues, and a high level of DPP-IV activity is found in the intestinal walls [2]. DPP-IV has shown specific action in the breakdown of gluten, among other proteins [3].

Proteases, also known as proteolytic enzymes, peptidase or proteinase are secreted naturally by the gut to breakdown dietary protein into smaller, absorbable peptides or amino acids [4]. They also break down unwanted bacteria, toxins, and cellular debris, complementing and relieving some roles of the immune system [4].

Amylase is produced naturally by salivary glands in the human body [5]. It is one of the most abundant salivary proteins and plays numerous roles in digestion, including hydrolyzing larger starch molecules into glucose and maltose for cellular transport and energy metabolism [5]. Glucoamylase, specifically, allows breaks down starch into d-glucose [6].

Some types of dietary fiber, such as insoluble plant polysaccharides (mainly cellulose and hemicelluloses; representing 20–30% of the dietary fiber ingested daily) cannot be broken down by human enzymes. However, probiotic bacteria (the microorganisms living in a healthy gut) produce some cellulase and hemicellulase, enzymes that break down these cell wall proteins to release valuable, absorbable nutrients from dietary plant material [7]. Supplementing cellulase and hemicellulase may aid in this process.

Alpha galactosidase is a naturally occurring human lysosomal glycosidase responsible for the hydrolysis of terminal a-galactosidic linkages in various glycolipids [8]. Xylanases are glycosidases not produced naturally by human cells but are also secreted by beneficial microorganisms in a healthy human gut [9]. Both glycosidases also aid in cellular breakdown and are especially beneficial to human digestion of plant material.

Lactose is the natural disaccharide sugar found in milk and dairy products, but the absorption of lactose requires enzymatic lactase activity in the small intestinal brush border [10]. Lactose malabsorption is the incomplete hydrolysis of lactose due to lactase deficiency, which may occur as a primary disorder or secondary to other intestinal diseases, and becomes an increasingly common condition with age, as lactase production by the gut tends to decline over time [10]. Supplementing lactase may aid in the digestion of dairy and ease the discomfort that often accompanies malabsorption.

Human lipases are secreted most abundantly by the stomach and the pancreas to aid in the digestion and assimilation of dietary fats [11]. Hepatic, lipoprotein and endothelial lipases are also secreted for the metabolism of lipoproteins [11]. Supplementation of these highly hydrophobic enzymes may aid in the digestion of dietary fats, and the absorption of valuable nutrients that are otherwise sequestered by lipid globules.


What are the Suggested Uses for GluDaZyme™?

Designed specifically to help those sensitive to gluten and dairy, GluDaZyme™ is suggested for those who may want to:

  • Optimize digestion of protein, fats, and carbohydrates - a wide variety of digestive enzymes support or bolster the body’s natural ability to break down ingested foods.
  • Enhance nutrient availability - enzymes help to release nutrients otherwise sequestered in large, undigested particles.
  • Help to ease the impact of common food sensitivities


Source Materials: Cellulose for capsules is derived from softwood tree pulp. All ingredients are vegan and non-GMO.


Allergens:  According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, fish, shellfish,  peanuts, tree nuts.


Recommendations: Use as directed by a healthcare professional.


Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.



  1. Detel, Dijana, Mladen Peršic, and Jadranka Varljen. "Serum and intestinal dipeptidyl peptidase IV (DPP IV/CD26) activity in children with celiac disease." Journal of pediatric gastroenterology and nutrition 45.1 (2007): 65-70.

  2. Drucker, Daniel J., and Michael A. Nauck. "The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes." The Lancet 368.9548 (2006): 1696-1705.

  3. Ehren, Jennifer, et al. "A food-grade enzyme preparation with modest gluten detoxification properties." PloS one 4.7 (2009): e6313.

  4. Group, Edward. “The Health Benefits of Protease.” Global Healing Center. (2013).

  5. Nater, Urs M., et al. "Human salivary alpha-amylase reactivity in a psychosocial stress paradigm." International Journal of Psychophysiology 55.3 (2005): 333-342.

  6. Thivend, P., CHRISTIANE MERCIER, and A. Guilbot. "Determination of starch with glucoamylase." General Carbohydrate Method. 1972. 100-105.

  7. Robert, Céline, and Annick Bernalier‐Donadille. "The cellulolytic microflora of the human colon: evidence of microcrystalline cellulose‐degrading bacteria in methane‐excreting subjects." FEMS microbiology ecology 46.1 (2003): 81-89.

  8. Bishop, David F., et al. "Human alpha-galactosidase A: nucleotide sequence of a cDNA clone encoding the mature enzyme." Proceedings of the National Academy of Sciences83.13 (1986): 4859-4863.

  9. Collins, Tony, Charles Gerday, and Georges Feller. "Xylanases, xylanase families and extremophilic xylanases."FEMS microbiology reviews 29.1 (2005): 3-23.

  10. Usai-Satta, Paolo, et al. "Lactose malabsorption and intolerance: what should be the best clinical management?."World journal of gastrointestinal pharmacology and therapeutics 3.3 (2012): 29.

  11. Mukherjee, Manjari. "Human digestive and metabolic lipases—a brief review." Journal of Molecular Catalysis B: Enzymatic22.5-6 (2003): 369-376.


* These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


Dairy and gluten digestive enzymes to aid digestion.
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  • Emma Stroud

    2018-04-21 07:03 pm

    I love this stuff i am only 11 years old and I have to take this because I have to be gluten free and this has done so much for me it makes it so when I take this and then I eat gluten it doesn't hurt me, it also helps my stomach heal from the pain

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