This hypoallergenic spray contains niacinamide, aloe vera, and Na-PCA (an amino acid moisturizer). Together they decrease blemishes, pore size, inflammation and redness. The spray should be used on clean skin to treat and seal the skin from outside contaminants.
Naturally Clear® Topical Spray
Product Code: 00003 Volume per Bottle: 4 oz.
Description: This hypoallergenic spray contains niacinamide, aloe vera, and Na-PCA (an amino acid moisturizer). Together they decrease blemishes, pore size, inflammation and redness. The spray should be used on clean skin to treat and seal the skin from outside contaminants.
Niacinamide, also known as nicotinamide or 3-pyridinecarboxamide, is the physiologically active form of niacin or vitamin B3. There is clinical evidence that niacinamide is an anti-acne active as it reduces the production of sebum (the pore-clogging, oily substance secreted by the skin), making it effective in alleviating symptoms of mild to moderate acne . It is also an up-regulator of epidermal sphingolipid synthesis, an up-regulator of markers of epidermal differentiation and dermal proliferation, as well as a moderator of photodamage repair . Cosmetically, topical niacinamide has been shown to help reduce yellowing, wrinkling, redness, blotchiness, and hyperpigmentation in facial skin . Topical niacinamide also provides potent anti-inflammatory activity. Skin cell studies suggest niacinamide may stimulate collagen production (a benefit associated with anti-aging effects) and facilitate wound healing .
The humectant Na-PCA, or sodium pyrrolidone carboxylic acid, is an amino acid moisturizer naturally occurring in the stratum corneum of human skin . Younger skin contains more Na-PCA than aging skin . Na-PCA is added to Naturally Clear® products to help the skin retain moisture, prevent dryness and flaking, and give skin a youthful glow.
Aloe vera is a popular ingredient in skin care products because of its well-known skin soothing, anti-fungal, and anti-inflammatory properties . In fact, records from Greece, Egypt, India, Mexico, Japan and China show that medicinal plants of the aloe genus have been used for over 2000 years to soothe many symptoms of skin disease [4,5]. Studies have shown topical aloe vera to be effective in healing minor skin infections, making scarring less likely . It contains six antiseptic agents: Lupeol, salicylic acid, urea nitrogen, cinnamonic acid, phenols and sulfur, all of which have an inhibitory effect on fungi, bacteria and viruses . Aloe vera has been demonstrated to protect skin from reactions to and damage caused by radiation (due to UV/sun exposure as well as therapeutic radiation) [5,6]. Giberellin, a component of aloe vera, also acts as a growth hormone, stimulating the growth of new cells . Aloe vera also improves skin’s hydration and elasticity while providing a refreshing sensation.
Source Materials: Niacinamide: chemical synthesis. Aloe vera: Aloe barbadensis inner leaf fillet juice. Sodium PCA: derived from the amino acid proline.
Allergens: According to information provided by our suppliers, this topical spray is free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.
Recommendations: Mist onto clean skin twice daily and let dry. For best results, use after cleansing with Naturally Clear® scrub or Naturally Clear® cleansing foam.
- Matts, Paul J., John E. Oblong, and Donald L. Bissett. "A review of the range of effects of niacinamide in human skin."Int Fed Soc Cosmet Chem Mag 5 (2002): 285-9.
- Bissett, D. L., et al. "Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin." International journal of cosmetic science 26.5 (2004): 231-238.
- Middleton, J. D., and Marese E. Roberts. "Effect of a skin cream containing the sodium salt of pyrrolidone carboxylic acid on dry and flaky skin." J Soc Cosmet Chem 29.4 (1978): 201-205.
- Dal'Belo, Susi Elaine, et al. "Moisturizing effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by skin bioengineering techniques."Skin Research and Technology 12.4 (2006): 241-246.
- Surjushe, Amar, Resham Vasani, and D. G. Saple. "Aloe vera: a short review." Indian journal of dermatology 53.4 (2008): 163.
- Williams, Maureen S., et al. "Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity." International journal of radiation oncology, biology, physics 36.2 (1996): 345-349.
- Davis, Robert H., and Nicholas P. Maro. "Aloe vera and gibberellin. Anti-inflammatory activity in diabetes." Journal of the American Podiatric Medical Association 79.1 (1989): 24-26.
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.