R.E.M. Maintenance™

60 SRVGS Product No. 00681

$48.00
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Recent research emphasizes the importance of sleep for cognition, cardiovascular health, and balanced mood. However, for many, restful sleep remains elusive. R.E.M. Maintenance is non-habit forming and provides nutrients that support both physical and mental relaxation. Melatonin and 5-HTP are provided to enhance sleep onset while the minerals magnesium and potassium aid muscle relaxation. Glycine enhances sleep quality while both glycine and inositol ease nervous tension.
 

  • Enhances sleep onset*
  • Promotes restful sleep*
  • Supports normal muscle relaxation*

* These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

R.E.M. Maintenance™

 

Product Code: 00681          Servings per Bottle: 60

 

Each scoop (6 g) contains:

 

Calories

10

Vitamin C (as Ascorbic Acid)

250 mg

Magnesium (as Magnesium Glycinate)

250 mg

Potassium (as Potassium Citrate)

75 mg

Glycine

3500 mg

Inositol

500 mg

5-Hydroxytryptophan

100 mg

Melatonin

1 mg

 

Overview:

Science shows that sleep is important for cognition, cardiovascular health, and balanced mood, but many of us aren’t getting the restful sleep we need. R.E.M. Maintenance is non-habit forming and provides nutrients that support both physical and mental relaxation. Melatonin and 5-HTP are included in the formula to help bring on sleep, magnesium and potassium aid in muscle relaxation, and both glycine and inositol ease nervous tension.

 

What is R.E.M. Maintenance™?

R.E.M. Maintenance™ powder is a unique blend of nutraceuticals formulated to support normal, healthy sleep. It is easily dissolved in liquids (water, tea, juice, etc.) for a calming bedtime drink.

 

How Does R.E.M. Maintenance™ Work?

R.E.M. Maintenance™ provides a combination of ingredients to support healthy sleep patterns including:

Melatonin is a hormone that is synthesized from serotonin and produced naturally by the pineal gland during hours of darkness. It is responsible for regulating the "body clock” that controls when you're awake and when your body is ready for sleep [1]. Melatonin supplements should be taken only in the evenings so that the highest levels of circulating melatonin occur when you are ready to bring on sleep, mimicking the natural cycle. Supplementing with melatonin alone will not change circulating levels of serotonin, or affect mood, but low levels of serotonin could be a cause for poor melatonin production and consequential difficulty sleeping [2]. 

5-hydroxytryptophan, better known as 5-HTP, is naturally produced by the body as a precursor for the production of serotonin. However, 5-HTP bypasses the light-triggering system that regulates the release of melatonin, and so provides the substrate for an increase in both serotonin and melatonin release, regardless of light or time of day. Because 5-HTP increases serotonin, it has a calming, relaxing effect on brain chemistry, and may help to ease any anxiety that occasionally arises at bedtime. Studies have shown that 5-HTP supplementation can help patients fall asleep faster and sleep more deeply than a placebo [3].

Inositol is used by your brain as a “secondary messenger”, facilitating communication between brain cells. All of the major neurotransmitters rely on inositol to relay messages. Inositol not only improves the effectiveness of serotonin, but also GABA, glutamate, and dopamine, to promote a stronger sense of well-being, more restful sleep at night, and a more even-tempered mood during the day [4]. 

Glycine is an amino acid that easily crosses the blood-brain barrier, inducing a calming effect on the brain, and helping you wind down to prepare for sleep. Glycine triggers the biological clock to reduce core body temperature through vasodilation, which is an important biological step in the onset of sleep [5]. Glycine also works as a neurotransmitter and has both stimulatory and inhibitory effects on parts of the brain and central nervous system. It is also involved in the production of other biochemicals that influence these body functions, including serotonin [6]. 

Magnesium and potassium are two minerals with a plethora of functions throughout the body. These are essential minerals because they are not produced by the body and must be consumed regularly in the diet in order to fulfill the body’s need for proper function. Magnesium deficiency is very common and associated with symptoms such as insomnia, leg cramping, and restless leg syndrome [7]. Magnesium is a regulator of the parasympathetic nervous system, the system responsible for promoting calm and relaxation [8]. It also helps to regulate melatonin [9] and GABA, the neurotransmitter responsible for quieting the nervous system [10]. 

Unfortunately, as we age, we tend to find less magnesium is being absorbed from our diet, and this problem can be exacerbated by conditions such as diabetes, digestive issues, or high alcohol consumption [11]. 

Potassium channels and their functions are essential to cell signaling and brain synapses. Potassium helps nerves and muscles communicate, and helps move nutrients into cells and to remove waste products from cells. Studies have shown that potassium supplementation helped participants sleep deeply, without interruption in sleep cycles [12].

 

What is The Suggested Use for R.E.M. Maintenance™?

  • Encouraging the onset of sleep: As we age, we tend to produce less and less melatonin [13]. This may be the reason new sleep difficulties often arise as we advance into our later years. Coupled with the change in body temperature brought on by glycine, a low dose of melatonin at bedtime can help to mimic the natural sleep cycles of our youth. 5-HTP and inositol may also help to ward off some of the anxiety that can prevent us from falling asleep.
  • Promoting restful sleep: Balanced serotonin production, signaling, and metabolism in response to a variety of quality nutrients may help us to stay asleep and feel rested upon waking. Potassium may help with brain cell detox during sleep and promoting uninterrupted sleep cycles.
  • Normal muscle relaxation: Magnesium is especially important for muscular relaxation, but complementary nutrients may help to counteract the effects of mental stress that can manifest physically.

Source Materials: Vitamin C is made from corn sorbitol. Magnesium and potassium are mined minerals. Glycine, inositol, and melatonin are made by chemical synthesis. 5-HTP is extracted from Griffonia simplicifolia seeds. Citric acid is from corn dextrose fermentation. Monk fruit extract is a water extract of Siraitia grosvenorii fruit.

 

Allergens: According to information provided by our suppliers, this powder is free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.

 

Recommendations: One (1) scoop (6 g) dissolved in water or beverage of choice at bedtime, or as directed by a healthcare professional. Drink immediately.

 

Precautions: R.E.M. Maintenance™ contains 5-HTP which should not be taken with MAO inhibitors or tricyclic antidepressants. May cause drowsiness. Do not drive or operate heavy machinery after taking this product. Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.

 

References:

  1. Erland, Lauren AE, and Praveen K. Saxena. "Melatonin natural health products and supplements: presence of serotonin and significant variability of melatonin content." Journal of Clinical Sleep Medicine 13.02 (2017): 275-281.
  2. Hardeland, Rüdiger. "Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction." The Scientific World Journal 2012 (2012).
  3. Cauffield, Jacintha S., and Hiroko Jm Forbes. "Dietary supplements used in the treatment of depression, anxiety, and sleep disorders." Lippincott's primary care practice 3.3 (1999): 290-304.
  4. Mukai, Tomohiko, et al. "A meta‐analysis of inositol for depression and anxiety disorders." Human Psychopharmacology: Clinical and Experimental 29.1 (2014): 55-63.
  5. Kawai, Nobuhiro, et al. "The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus." Neuropsychopharmacology 40.6 (2015): 1405.
  6. Breus, Micheal. “Understanding Glycine”. The Sleep Doctor. July 23, 2018. https://thesleepdoctor.com/2018/07/23/understanding-glycine/
  7. Popoviciu, L., et al. "Clinical, EEG, electromyographic and polysomnographic studies in restless legs syndrome caused by magnesium deficiency." Revue Roumaine de Neurologie et Psychiatrie (1993).
  8. Wienecke, E., and C. Nolden. "Long-term HRV analysis shows stress reduction by magnesium intake." MMW Fortschritte der Medizin 158.Suppl 6 (2016): 12-16.
  9. Durlach, J., et al. "Biorhythms and possible central regulation of magnesium status, phototherapy, darkness therapy and chronopathological forms of magnesium depletion." Magnesium research 15.1-2 (2002): 49-66.
  10. Poleszak, Ewa. "Benzodiazepine/GABAA receptors are involved in magnesium-induced anxiolytic-like behavior in mice." Pharmacological Reports 60.4 (2008): 483.
  11. National Institutes of Health. Magnesium Fact Sheet for Professionals. Accessed Dec 10, 2018. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/.
  12. Cornelius, Jason R., et al. "Sleep manifestations of voltage-gated potassium channel complex autoimmunity." Archives of neurology 68.6 (2011): 733-738.
  13. Sack, Robert L., et al. "Human melatonin production decreases with age." Journal of pineal research 3.4 (1986): 379-388.

 

* These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

R.E.M. Maintenance™
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