Product Code: 00551 Capsules per Bottle: 60
Each vegetarian cellulose capsules contains:
Folate (15mg from 20.5mg L-5-Methylfolate, calcium salt)
Other ingredients: vegetarian cellulose capsule
Description: Folic acid, the most common form of folate in supplements and fortified foods, requires the enzyme methylenetetrahydrofolate reductase (MTHFR) to be converted to L-methylfolate, the activated form of folate used by the body for many biochemical reactions. About half of the population have genetic variations that reduce the ability of the MTHFR enzyme to make this conversion. For this population, L-methylfolate supplementation is far more effective in providing this form of folate. Metabolic Maintenance offers a clean nutritional option for L-methylfolate, that is free of allergens, preservatives, food coloring and binders. Additionally, all Metabolic Maintenance capsule products are packaged in amber glass bottles to avoid the dangers of plastic contaminants.
Uses: Methylation is a biochemical process involved in almost all of the body’s functions. It is the addition of a single carbon and three hydrogen atoms (called a methyl group) to another molecule. The removal of a methyl group is called demethylation. A healthful diet and adequate nutrition, supported by supplementation, can improve your methylation pathways and boost your health. B vitamins are methyl donors, especially folate, B6, B12 and riboflavin, but they cannot be used efficiently by the body unless some critical enzymes are present. One such enzyme is Methylenetetrahydrofolate reductase.
MTHFR is a gene that provides instructions to make an enzyme called methylenetetrahydrofolate reductase. Methylenetetrahydrofolate reductase is a necessary factor for a chemical reaction breaking down folate (folic acid/vitamin B9) to its active form, L-methylfolate (5-MTHF). Specifically, this enzyme converts a molecule called 5,10-methylenetetrahydrofolate to a molecule called 5-methyltetrahydrofolate. This reaction is also required to convert the amino acid homocysteine to another amino acid, methionine. The body uses methionine to make proteins such as the neurotransmitters; dopamine, serotonin, melatonin, and epinephrine. It is through this pathway, that L-methylfolate has a regulatory effect on mood.
It has been estimated that up to 60% of Americans carry an inherited mutation in the MTHFR gene. Although there are many variations of the gene, the two most studied functional mutations (also known as polymorphisms) of the gene are MTHFR C677T and MTHFR A1298C. While many people with mutations in this gene will live a normal life without experiencing symptoms, some individuals experience a drop in enzyme efficiency by 30-70%, depending on the variant of the mutation. If this is the case, folate cannot be converted to L-methylfolate, homocysteine will not be efficiently broken down into methionine, and the production of neurotransmitters may slow, dramatically affecting mood. Unconverted folate and homocysteine levels build up in the blood without consistent conversion, and elevated homocysteine in the blood is a known, independent risk factor for heart disease, stroke, and other forms of cardiovascular disease.
Only a genetic test by your doctor can confirm whether or not you have a MTHFR mutation, but if you do, L-methylfolate supplementation could be the answer. L-Methylfolate bypasses the entire folic acid metabolism cycle and has been shown to be more effective than folic acid for increasing circulating folate in those with an MTHFR mutation. L-Methylfolate is also highly effective at reducing homocysteine levels in healthy people (without an MTHFR mutation). It is better absorbed and interacts with fewer medications than folic acid.
Source Materials: L-methylfolate, calcium salt (Extrafolate S®, Gnosis Bio, Italy) and glycine are made by chemical synthesis. All ingredients are vegan and non-GMO.
Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.
Recommendations: Use as directed by a healthcare professional.
Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.
- LeBano, Lauren. “L-Methylfolate: A Promising Therapy for Treatment-Resistant Depression?” Psyche Congress Network. May 8, 2013. www.psychcongress.com/article/l-methylfolate-promising-therapy-treatment-resistant-depression
- Leech, Joe. “L-Methylfolate (5-MTHF): Your Must-Read Beginner’s Guide.” Diet vs. Disease. May 13, 2018. https://www.dietvsdisease.org/l-methylfolate-5-mthf/
- Papakostas, George I., et al. "L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials." American Journal of Psychiatry 169.12 (2012): 1267-1274.
- Patanwala, Imran, et al. "Folic acid handling by the human gut: implications for food fortification and supplementation–."The American journal of clinical nutrition 100.2 (2014): 593-599.
- Stahl, Stephen M. "Brainstorms: L-Methylfolate: A Vitamin for Your Monoamines." The Journal of clinical psychiatry 69.9 (2008): 1352-1353.
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.