180 CAPS | 2 MG Product No. 00634

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Melatonin, a hormone we all produce naturally, is intimately involved in synchronizing the body's hormone secretions, setting the brain's internal clock and generating circadian rhythms. Preliminary findings suggest it may help support normal nerve function and healthy blood pressure.

  • Promotes restorative sleep*
  • Supports healthy blood pressure*
  • Aids in protecting nerve health*

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.



Product Code: 00634            Capsules per Bottle: 180


Each size 3 vegetarian cellulose capsule contains:



2 mg


210 mg

  Other ingredients: vegetarian cellulose capsule


Description: The naturally occurring pineal hormone, melatonin, is involved in the circadian regulation and facilitation of sleep, the inhibition of cancer development and growth, and the enhancement of immune function [1].


Uses: Some studies suggest that a shortened duration of nocturnal sleep is associated with immune suppression and a higher risk of disease [1]. Presently, scientific evidence is accumulating to support melatonin supplementation as a useful aid in achieving restful sleep for patients with some types of insomnias and circadian rhythm sleep disorders (CRSDs) [2]. Insomnia and CRSDs, whether chronic or transient, affect a wide range of individuals, including many adults of advanced ages, those with severe visual impairments, shift workers, and travelers moving across many time zones. A feature common among CRSDs and some forms of insomnia is sensitivity to the hormone melatonin, which is secreted naturally by healthy, normal pineal glands during periods of darkness [1, 2]. Clinical data suggest that exogenous melatonin may help to regulate the circadian clock located in the suprachiasmatic nucleus of the hypothalamus [2]. As the circadian clock is involved in autonomic cardiovascular regulation, nighttime melatonin intake has also been shown to help regulate blood pressure [3].


Outside of the pineal gland, gastrointestinal tissue contains the highest concentrations of naturally occurring melatonin [4]. There, melatonin has been demonstrated to prevent ulcerations of gastrointestinal mucosa by an antioxidant action, reduce secretion of hydrochloric acid, stimulate the immune system, foster epithelial regeneration, and increase microcirculation [4].


Melatonin can also be secreted naturally by other tissues including retina, Harderian glands, gut, ovary, testes, bone marrow and lens, suggesting its importance in the function of these tissues [5]. Several studies have shown that melatonin reduces chronic and acute inflammation, and as a consequence, melatonin improves the clinical course of illnesses which have an inflammatory etiology [5]. The immunomodulatory properties of melatonin are well known; it acts on the immune system by regulating cytokine production of immunocompetent cells, reduces adhesion molecules and pro-inflammatory cytokines and modifies serum inflammatory parameters.


Melatonin is also both a direct and indirect antioxidant, scavenging free radicals, stimulating antioxidant enzymes, enhancing the activities of other antioxidants or protecting other antioxidant enzymes from oxidative damage [5]. Moreover, recent studies have implicated melatonin as a neuroprotective molecule in neurodegenerative disorders where brain oxidative damage has taken place [5].


Source Materials: Melatonin is made by chemical synthesis. Cellulose for capsules is derived from softwood tree pulp. All ingredients are vegan and non-GMO.


Allergens:  According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, fish, shellfish, peanuts, tree nuts.


Recommendations: Use as directed by a healthcare professional.


Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.



  1. Blask, David E. "Melatonin, sleep disturbance and cancer risk." Sleep medicine reviews 13.4 (2009): 257-264.
  2. Turek, Fred W., and Martha U. Gillette. "Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists." Sleep medicine 5.6 (2004): 523-532.
  3. Scheer, Frank AJL, et al. "Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension."Hypertension 43.2 (2004): 192-197.
  4. Esposito, Emanuela, and Salvatore Cuzzocrea. "Antiinflammatory activity of melatonin in central nervous system." Current neuropharmacology 8.3 (2010): 228-242.
  5. Bubenik, George A. "Gastrointestinal melatonin: localization, function, and clinical relevance." Digestive diseases and sciences 47.10 (2002): 2336-2348.



These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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