Although the body has the ability to convert L-Carnitine to Acetyl-L-Carnitine and vice versa, the supplements are effective for supporting different functions. L-Carnitine is essential for transporting long-chain fatty acids across the mitochondrial membrane for subsequent fat breakdown and energy generation. Because of its role in energy generation, L-Carnitine has a broad array of health benefits including weight management, recovery after exercise, cardiovascular health (the heart gets 70% of its energy from fat breakdown), male fertility, healthy aging, and infant nutrition.* *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Product Code: 00124 Capsules per Bottle: 60
Each size 1 vegetarian cellulose capsule contains:
L-Carnitine (as 373 mg L-Carnitine Tartrate)
Description: Although the body can convert L-carnitine to acetyl-L-carnitine and vice versa, different forms of carnitine are effective for supporting different functions. L-Carnitine is essential for transporting long-chain fatty acids across the mitochondrial membrane for subsequent fat breakdown and energy generation . L-Carnitine also shuttles short chain fatty acids from inside the mitochondria to the cytosol. Therefore, L-carnitine is, in part, responsible for maintaining energy metabolism throughout the body .
Uses: L-Carnitine is especially relevant to cardiovascular energy metabolism, as the heart gets 70% of its energy from fat breakdown and free fatty acids are the preferred energy substrate for myocardial oxidative metabolism . Myocardial carnitine levels are quickly diminished during ischemic events, and exogenous supplementation with L-carnitine has been shown to replenish depleted myocardial carnitine levels for efficient cardiac metabolism and left ventricular function .
Supplementation with L-carnitine has also been linked to improvements in measures of evoked muscular potential . While a great deal of research has been dedicated to carnitine supplementation for enhanced lipid oxidation, spare muscle glycogen, and improved exercise performance, the most significant benefits of L-carnitine, in terms of performance, have been documented in populations with certain existing health conditions, particularly those with various dimensions of cardiovascular disease [3, 4]. The muscular benefits of this supplement for the general, healthy population appear to be related to the recovery process after exercise . L-Carnitine has been shown to mediate the markers of purine catabolism, reduce tissue damage, and facilitate the overall process of recovery . The positive effects of L-carnitine in recovery from stress are thought to act via a cell/tissue-related mechanism, through which oxygen availability is enhanced, and hypoxic stress, free radical formation, membrane disruption, and muscle soreness are reduced .
Because of its role in energy generation, L-carnitine has shown a broad array of other health benefits including weight management. Scientific investigations conclude that L-carnitine may decrease fat deposition in favor of protein deposition and improve utilization of dietary fat . Additionally, increased fat oxidation observed after L-carnitine supplementation is not accompanied by any observed protein catabolism , indicating a synergistic role for this nutrient in a weight management plan that includes regular exercise.
L-carnitine supplementation has also been shown to support male fertility [5,6]. Part of the physiological role of the epididymis is the epithelial secretion of relatively high levels of carnitines for mitochondrial beta-oxidation of long-chain fatty acids (and subsequent energy metabolism) within spermatozoa . By providing readily available energy for use by spermatozoa, and thus positively affecting sperm motility, maturation and the spermatogenic process, a key role in sperm quality is strongly suggested for L-carnitine.
L-Carnitine also has a protective effect on DNA and membranes against damage induced by free oxygen radicals .
The multi-faced antioxidant effects of L-carnitine also demonstrate value for this supplement in healthy aging . Additionally, clinical studies show promising results related to improved cognitive function with L-carnitine supplementation .
Source Materials: L-carnitine tartrate is made by chemical synthesis. Cellulose for capsules is derived from softwood tree pulp. All ingredients are vegan and non-GMO.
Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, fish, shellfish, peanuts, tree nuts.
Recommendations: Use as directed by a healthcare professional.
Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.
- Wutzke, Klaus D., and Henrik Lorenz. "The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects." Metabolism-Clinical and Experimental 53.8 (2004): 1002-1006.
- DiNicolantonio, James J., et al. "L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis." Mayo Clinic Proceedings. Vol. 88. No. 6. Elsevier, 2013.
- Kraemer, William J., Jeff S. Volek, and Courtenay Dunn-Lewis. "L-carnitine supplementation: influence upon physiological function." Current sports medicine reports 7.4 (2008): 218-223.
- Volek, Jeff S., et al. "L-Carnitine L-tartrate supplementation favorably affects markers of recovery from exercise stress."American Journal of Physiology-Endocrinology and Metabolism 282.2 (2002): E474-E482.
- Lenzi, Andrea, et al. "Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial. “Fertility and sterility 79.2 (2003): 292-300.
- Zhou, Xin, Fang Liu, and Suo-Di Zhai. "Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review." Asia Pacific journal of clinical nutrition 16.S1 (2007): 383-390.
- Gülcin, İlhami. "Antioxidant and antiradical activities of L-carnitine." Life sciences 78.8 (2006): 803-811.
- Montgomery, Stuart A., L. J. Thal, and R. Amrein. "Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. “International Clinical Psychopharmacology 18.2 (2003): 61-71.
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.