The power of the gastrointestinal (GI) microbiome over human health is becoming increasingly apparent. Over 500 different microorganisms have been identified from the human gut. Beneficial microorganisms produce compounds including digestive enzymes and lactic acid that keep our bowels and body functioning well. Many pathogenic organisms also reside there, but will not overgrow and become a problem unless the bowel environment becomes imbalanced from stress, poor diet, introduction of more pathogens or use of antibiotics. This is called dysbiosis. Dysbiosis can produce GI discomfort, and interfere with proper nutrition and immune function. Happy Belly® was formulated in collaboration with MetaMetrix Labs after examining over 3,000 stool tests. The ingredients chosen are the ones found most effective for ridding the gut of harmful organisms and restoring a normal balance of microorganisms to the GI tract.
Happy Belly® Dysbiosis Formula
Product Code: 00661 Capsules per Bottle: 90
Each serving of 2 size 00 vegetarian cellulose capsules contains:
Magnesium (from Magnesium Caprylate)
Caprylic Acid (from Magnesium Caprylate)
Proprietary Herbal Blend:
Barberry Root Extract (Berberis vulgaris, standardized to 6% berberine), Oregon Grape Root Extract (Berberis aquifolium, 4:1), Garlic Bulb Extract ( Allium sativum, standardized to 1% alliin), Black Walnut Hull Extract (Juglans nigra, 4:1),
Olive Leaf Extract (Olea europaea, standardized to 18% oleuropein)
Other ingredients: L-leucine.
Description: Formulated in collaboration with MetaMetrix labs, Happy Belly® contains the ingredients found most effective for ridding the gut of harmful organisms and restoring a normal balance of microorganisms to the gastrointestinal (GI). tract.
Uses: Dysbiosis is an imbalance of the GI microbiome caused by overgrowth of pathogenic microorganisms. It can be caused by stress, poor diet, use of antibiotics, or introduction of pathogens from the environment. This overgrowth displaces beneficial bacteria that produce compounds including digestive enzymes and lactic acid that keep our bowels and our body functioning well. Dysbiosis can produce GI discomfort, and interfere with proper nutrition and immune function.
The ingredients: Caprylic acid is a fatty acid that has antifungal and antibacterial properties. It is produced by the body in small quantities and can be extracted from plant fats, such as coconut oil and palm oil. Taking caprylic acid in supplement form is often recommended for Candida overgrowth syndrome. Bloating, gas, diarrhea, fatigue, headache, depression, and repeated vaginal yeast infections are some of the symptoms of Candida overgrowth. Caprylic acid has also been shown to be effective against common Streptococcus and Staphylococcus pathogens. (1)
Barberry (Berberis vulgaris) and Oregon Grape(Berberisaquifolium) are two herbal extracts that contain berberine—an antimicrobial alkaloid. Berberine containing herbs have a long history of use in Chinese medicine for treatment of intestinal infections. Recent research has shown that berberine caused structural modulation of gut micoflora, leading to reduced inflammation (2). Another recent studyreported that Oregon Grape contains a specific multi drug resistance pump inhibitor (MDR Inhibitor)- 5'methoxyhydnocarpin- that works in synergy with berberine by reducing the resistance of pathogens to antimicrobial compounds (3).
Garlic (Allium sativum) contains the sulfur compound alliin, which has antifungal properties and can inhibit Candida growth (4).Garlic has also been found to be effective against Aspergillus infections (5).
Black Walnut (Juglansnigra) extract has been traditionally used to help eliminate parasites from the body. The tannin constituents from Black walnut have antibacterial activity, and were found to be especially active against Listeria monocytogenes (6).
Olive (Oleaeuropaea) leaf extract contains oleuropein, a polyphenolic compound with antioxidant and anti-inflammatory properties. Oleuropein is gastroprotective, strengthening the mucosal barrier (7). Oleuropein shows promise in protecting against chronic colitis (8).
Source Materials: Magnesium caprylate is made by reacting magnesium oxide with caprylic acid (a fatty acid from palm oil). All herbal extracts in the Proprietary Herbal Blend are ethanol/water extracts of the species and plant part indicated. L-leucine is derived from fermentation of cane sugar. Cellulose for capsules is derived from softwood tree pulp. All ingredients are vegan and non-GMO.
Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.
Recommendations: Use as directed by a healthcare professional.
Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.
- Nair MK, Joy J, Vasudevan P, et al (2012). Antibacterial effect of caprylic acid and monocaprylin on major bacterial mastitis pathogens. Int J Mol Sci; 13(2):1426-36.
- Zhang X, Zhao Y, Zhang M, et al (2012) structural changes of gut microflora during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. PLoS One 7(80: e42529. Doi:10.1371/journal.pone.0042529
- Strmitz, FR, Lorenz P, Tawara JN, et al (2000). Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor. Proc Natl Acad Sci USA, Feb 15;97(4):1433-7
- Chung I, Kwon SH, shim ST, Kyung KH (2007). Synergistic antiyeast activity of garlic oil and allyl alcohol derived from alliin in garlic. J Food Sci Nov;72(9): M437-40.
- Shadkchan Y, Shemesh E, Mirelman D, et al (2004). Efficacy of allicin, the reative molecule of garlic, in inhibiting Aspergillus spp. In vitro, and if a murine model of disseminated aspergillosis. J Antimicrob Chemother May;53(5):832-6. Epub 2004 Mar 24.
- Amarowicz R, Dykes, GA, Pegg RB (2008). Antibacterial activity of tannin constituents from Phaseolus vulgaris, Fagoypyrum esculentum, Corylus avallana and Juglans nigra. Fitoterapia Apr;79(3):217-9. Epub 20008 Feb 9
- Sumbul S, ahmad MA, Mohd A, Mohd, A (2011). Role of phenolic compounds in peptic ulcer: an overview. J Pharm Bioallied Sci Jul-sept;3(3): 361-367.
- Giner E, Recio MC, Rios JL, Giner RM (2013). Oleuropein protects against dextran sodium sulfate-induced chronic colitis in mice. J Nat Prod June 28;76(6):1113-20. Epub 2013 Jun 12.
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.