NERVEsustain™ Peripheral Nerve Support

30 CAPS Product No. 00525

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NERVEsustain™ is formulated with an array of bioactive B vitamins that are integral to the maintenance of proper nerve function. 

NERVEsustain™ also supports healthy homocysteine levels. High homocysteine and associated MTHFR polymorphisms are risk factors in diminished nerve health. 

Healthy blood glucose is also associated with the longevity of nerve health. Unfortunately, certain common medications given to balance blood glucose can contribute to the depletion of important B vitamins. 

Protect nerve health with optimal amounts of supportive nutrients delivered in a single daily capsule.


  • Nourishes healthy nerve function and structure*
  • Provides key nutrients for homocysteine metabolism*
  • Delivers bioactive forms of B vitamins, including L-methylfolate
  • Supplies optimal amounts of nerve supportive nutrients in a single daily capsule


* These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

NERVEsustainTM Peripheral Nerve Support


Product Code: 00525            Capsules per Bottle: 30


Each size 0 vegetarian cellulose capsule contains:


Vitamin C (as Ascorbyl Palmitate)


Thiamine (as Thiamine Mononitrate)

50 mg

Riboflavin (as Riboflavin 5’ Phosphate)

40 mg

Vitamin B-6 (as Pyridoxal 5’ Phosphate)

70 mg

Folate (6 mg folate from 8.25 mg L- 5- Methylfolate, calcium salt)

10 mg DFE

Vitamin B-12 (as Methylcobalamin)

4 mg

Magnesium (as Magnesium Citrate)

50 mg

Other ingredients: vegetarian cellulose capsule


Product Description: 

What is NERVEsustain?

NERVEsustain™ for Peripheral Nerve Support is designed to provide a full range of B vitamins associated with protecting and maintaining nerve health. Healthy nerves rely on adequate levels of several specific B vitamins, but life’s circumstances, certain health conditions, and common medications can all stand in the way of attaining those levels [1]. 

Some functions that require the intake of specific vitamins may be negatively affected by common medications (such as Metformin), which can deplete levels of certain B vitamins [2,3]. Additionally, an MTHFR genetic polymorphism can affect the body’s ability to properly process folate. 

Separate from vitamin deficiency, nerve health is significantly affected by glucose balance. Imbalanced glucose levels can, over time, lead to symptoms of burning, tingling, and numbness in the extremities. These effects may be exacerbated by vitamin deficiency [2,3]. Designed to protect nerve health as conveniently as possible, NERVEsustain™ delivers optimal amounts of nutrients in a single daily capsule.


How does NERVEsustain Work?

NERVEsustain™ contains L-5-MTHF (L-methylfolate; Vitamin B-9), the bioactive form of folate. A deficiency of folate is known to cause symptoms associated with nerve dysfunction. A deficiency of folate is also associated with high homocysteine levels, yet another risk factor for an increased incidence of nerve dysfunction. Folate needs may be increased in those taking medications that are known to deplete folate, including anticonvulsants [5], oral contraceptives [7], and medications designed to control blood sugar [6]. In addition, useful folate levels are affected in a certain percentage of the population with the MTHFR gene polymorphism. The C677T polymorphism is associated with a greater risk of both high homocysteine [8] and diabetic neuropathy [9,10]. L-methylfolate is the bioactive form of folate that bypasses the MTHFR enzyme, and so is useful for all consumers, with or without genetic abnormalities.

Methylcobalamin (Vitamin B-12) is another vitamin that can cause neuropathic issues when levels are depleted [1]. The myelin sheath that surrounds nerves both protects them and aids in the fast transmission of information. A B-12 deficiency can lead to the degradation of this protective sheath, leading to damage to nerves and symptoms of tingling, burning, and numbness. B-12 is also a cofactor involved in maintaining normal homocysteine levels.

Vitamin B-12 deficiency is common, especially in the elderly and in strict vegetarians. B-12 levels are also influenced by the amount of stomach acid present in an individual and the intrinsic factors available to assist in absorption—these tend to wane as people age and are negatively influenced by common medications that reduce stomach acid. Gastric bypass surgery and issues from Crohn’s and ulcerative colitis can also result in difficulty absorbing B-12. Fortunately, studies show that oral B-12 supplementation can be as effective as injections for replenishing body stores [11]. 

Pyridoxal 5’ Phosphate (Vitamin B-6) deficiency can also contribute to nerve dysfunction manifesting as tingling and pain in hands and feet [1]. Antibiotics, oral contraceptives, and the class of antidepressants known as “monoamine oxidase inhibitors” can all deplete B-6. B-6 is a cofactor needed for the remethylation of homocysteine to methionine.

Riboflavin is involved in the healthy metabolism of other B vitamins, including folate and B-6. As such, it has a positive influence over homocysteine levels. It is also a cofactor for the MTHFR enzyme, aiding in the remethylation of homocysteine to methionine.

Thiamine is depleted by excessive alcohol consumption. Alcohol use can create alcohol-induced neuropathy, which can be made worse by the depleting effect of alcohol on body stores of thiamine [1].

Magnesium is involved in the normal transmission of nerve impulses. When glucose levels are high, the body requires more magnesium, which means those with diabetes are at a higher risk of magnesium deficiency [12]. Magnesium is involved in modulating normal insulin response.

Ascorbyl Palmitate is a fat-soluble form of vitamin C. Vitamin C is a powerful antioxidant for tissue protection and some studies have shown it has the potential to boost the bioavailability of L-methylfolate [13].

High homocysteine is associated with a greater risk of peripheral neuropathy in those suffering from diabetes [8,14,15]. The MTHFR C677T polymorphism (homozygous) is associated with an increased risk of high homocysteine levels [8], as well as the depletion of folate, B-12, and B-6. The combination of L-methylfolate and methylcobalamin is important for the reduction of homocysteine, and both B-6 and riboflavin act as cofactors in this process. 


What are the Suggested Uses for NERVEsustain?

  • Nourishes healthy nerve function and structure with bioactive forms of B vitamins (including L-methylfolate) and other essential nutrients in a single daily capsule.*
  • Provides key nutrients for normal homocysteine metabolism.*


Source Materials: Ascorbyl palmitate is derived from ascorbic acid (corn sorbitol) and palmitic acid (palm oil). Riboflavin 5’ phosphate is synthesized from riboflavin (fermentation). Methylcobalamin is derived by fermentation. Thiamine Mononitrate, Pyridoxal 5' phosphate, and L-methylfolate are synthetic.


Vegan Statement: NERVEsustainTM contains no ingredients derived from animal sources. Suitable for vegans.


Allergens:  According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.


Recommendations: Use as directed by a healthcare professional.


Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.



  1.  Hammond N, Wang Y, Dimachkie M, Barohn R. Nutritional neuropathies. Neurol Clin. 2013 May; 31(2):477-489.
  2. Wile D, Toth C. Association of metformin, elevated homocysteine,and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy. Diabetes Care. 2010 Jan;33(1): 156-161.
  3. Gupta K, Jain A, Rohatgi A. An observational study of vitamin B12 levels and peripheral neuropathy profile in patients of diabetes mellitus on metformin therapy. Diabet Metab Syndr. 2018 Jan-Mar;12(1):51-58.
  4. Yilmaz M, Aktug H, Oltulu F, Erbas O. Neuroprotective effects of folic acid on experimental diabetic peripheral neuropathy. Toxic Ind Health. 2016 May; 32(5): 832-40.
  5. Martinez Figueroa A, Johnson RH, Lambie DG, Shakir RA. The role of folate deficiency in the development of peripheral neuropathy caused by anticonvulsants. J Neurol Sci. 1980 Dec;48(3):315-23.
  6. Wulffele MG, Kooy A, Lehert P, et al. Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med. 2003; 254: 455-463.
  7. Wilson SM, Bivens BN, Russel KA, Bailey LB. Oral Contraceptive use: impact on folate, B6 and vitamin B 12 status. Nutr Rev. 2011 Oct; 69(10): 572-83.
  8. Refsum H, Nurk E, Smith AD, et al. The Hordaland homocysteine study: a community-based study of homocysteine, its determinants and associations with disease. J Nutr. 2006; 136: 1731S-40S.
  9. Wu S, Han Y, Hu Q, et al. Effects of common polymorphisms in the MTHFR and ACE genes on diabetic peripheral neuropathy progression: a meta-analysis. Mol Neurobiol. 2017 May; 54(4): 2435-2444.
  10. Yigit S, Karakus N, Inanir A. Association of MTHFR gene C677T mutation with diabetic peripheral neuropathy and diabetic retinopathy. Mol Vis. 2013 Jul;19: 1626-30.
  11. Vidal-Alaball J, Butler CC, Cunnings-John R, et al. Oral vitamin B12 versus intramuscular B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2005; (3): 00004655.
  12. Barbagallo M, Dominguez L. Magnesium and type 2 diabetes. World J Diabetes. 2015 Aug 25; 6(10): 1152-1157.
  13. Verlinde PN, Oy I, Hendrickx ME, et al. L-ascorbic acid improves the serum folate response to an oral dose of [6S]-5-methyltetrahydrofolic acid in healthy men. Eur J Clin Nutr. 2008; 62 (10): 1224-1230.
  14. Ansari R, Mahta A, Mallack E, Luo JJ. Hyperhomocysteinemia and neurologic disorders: a review. J Clin Neurol. 2014 Oct;10 (4): 281-288.
  15. De Luis DA, Fernendez N, Arranz ML, et al. Total homocysteine levels relation with chronic complications of diabetes, body composition and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2. J Diabet Complications. 2005 Jan; 19(1): 42-46.


* These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


NERVEsustain™ Peripheral Nerve Support
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