VitalEyes™ Complete Ocular Formula*

90 CAPS Product No. 00229

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Maintaining vision correlates with increased independence in advancing age. VitalEyes™ Complete is a research-based ocular support multivitamin/mineral formula, with potent antioxidant protection important to visual health. Updates to VitalEyes™ Complete include zinc levels that reflect effective amounts in recent studies and enhancement with OmniActive's Lutemax® 2020, a lutein/zeaxanthin blend which acts in the eye to filter blue light from modern devices and aid in photo-stress recovery.

  • Provides research-backed ocular support within a full spectrum multivitamin*
  • Lutemax® 2020, bilberry extract and zinc aid healthy visual function*
  • Delivers essential B vitamins for healthy methylation and energy processes*
  • Supplies a broad spectrum of antioxidants for ocular and overall health*


*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

VitalEyes™ Complete Ocular Formula*


Product Code: 00229        Capsules per Bottle: 90


Each serving of 3 size 00 vegetarian cellulose capsule contains:

Vitamin A (18000 IU as Natural Mixed Carotenoids)

5400 mcg RAE

Vitamin C (as Ascorbic Acid)

500 mg

Vitamin D-3 (3000 IU as Cholecalciferol)

75 mcg

Vitamin E (200IU as d-Alpha Tocopheryl Acid Succinate)

133 mg

Thiamin (as Thiamin Mononitrate)

10 mg

Riboflavin (as Riboflavin 5’ Phosphate)

15 mg

Niacin (as Niacinamide)

25 mg NE

Vitamin B-6 (as Pyridoxine HCl and Pyridoxal 5’ Phosphate)

15 mg

Folate (400 mcg as L-5- Methylfolate, glucosamine salt)

667 DFE

Vitamin B12 (as Methylcobalamin)

100 mcg


300 mcg

Pantothenic Acid (as Calcium D-Pantothenate)

25 mg

Zinc (as Zinc Citrate)

30 mg

Selenium (as L-Selenomethione)

200 mcg

Copper (as Copper Bis-Glycinate)

2 mg

Manganese (as Manganese Glycinate)

10 mg

Chromium (as Chromium  Niacinate)

200 mcg

Molybdenum (as Molybdenum Glycinate)

25 mcg


100 mg

Lemon Bioflavonoids

100 mg

Lipoic Acid

100 mg

Bilberry Fruit Extract (Vacccinium myrtillus, standardized to 32% anthocyanosides)

75 mg

Coenzyme Q10

30 mg

Lutein (from Lutemax 2020)

20 mg

Zeaxanthin Isomers (from Lutemax 2020)

4 mg

Other ingredients: vegetarian cellulose capsule, L-leucine. Vitamin D is derived from lanolin. Natural vitamin E is derived from soy oil.


Description: Aging is a strong risk factor for visual impairment [1]. Maintaining vision correlates with increased independence for America’s rapidly aging population [2,3]. Because it is rich in nerve tissue and small blood vessels, the eye is especially vulnerable to threats from oxidative damage from free radicals. Factors that may potentially impact eye health include sunlight [4], unstable blood sugar [5] and diets low in antioxidants and high in inflammatory foods [6]. VitalEyes™ Complete is a research-based ocular protection formula, strong in antioxidant protection, provided within a comprehensive multi-vitamin/mineral supplement. It was designed according to three well-known large research studies- AREDS [7], AREDS2 [8], and Veteran’s LAST [9] that measured the effects of nutrients and antioxidants on age-related macular degeneration and decreased vision. As nearly 9 out of 10 participants in the second AREDS trial were on a multivitamin in addition to the AREDS formula [8} a combined product is an efficient and cost-effective choice. Choose VitalEyes™ Complete for research-backed eye health support provided within a daily multivitamin.

Ocular Health Support featured in the AREDS studies:

Vitamin C: A powerful antioxidant, vitamin C is the most prevalent antioxidant in the eye, tissue that is vulnerable to reactive oxygen species. Studies have shown that ascorbic acid may protect the retina from oxidative insults from light [10]. In addition, a higher intake of vitamin C has been associated with a reduced risk of eye disease related to oxidative stress, including neovascular AMD [6,11].

Vitamin E: A potent fat-soluble antioxidant, vitamin E has been shown to reduce the biomarkers of total oxidative stress and inflammation in the body [12]. The dietary intake of alpha tocopherol has been associated with a reduced risk of neovascular AMD [11].

Zinc: An essential trace mineral, zinc aids in bringing vitamin A to the eyes to produce melanin, a protective pigment. Zinc deficiency is associated with impaired vision [11]. Some studies suggest that supplementation with zinc may slow the rate of progression of macular degeneration [7,8]. The current zinc levels in VitalEyes™ Complete reflect the lower doses tested in the AREDS2 trial as effective to support macular health [8].

Lutein and Zeaxanthin isomers: the only three carotenoids found in the macula, these phytonutrients have long been associated with eye health. They are known to act as blue light filters and have antioxidant properties that may aid in macular health protection. When added to the second AREDS trial, an increase of efficacy was seen in slowing progression to advanced AMD [8].

Our current VitalEyes™ formulation features Lutemax® 2020 from OmniActive. Lutemax® 2020 provides lutein and both isomers of zeaxanthin (RR and RS (meso) zeaxanthin) in the 5 to 1 ratio that is found naturally in the diet. Each of these nutrients protects a different area of the macula [14]. Lutemax® 2020 provides the only lutein that has been USP verified. OmniActive is committed to supplying research to back their superior ingredients and multiple clinical studies have shown benefits to eye health, including positive effects on macular health, photo-stress recovery, blue light filtering and visual performance [15].

OmniActive, which provides Lutemax® 2020, takes social responsibility seriously and has initiatives supporting its agricultural provider communities including assured crop buy back and supporting choices that positively impact the environment. They also support the health of the rural communities by partnering with local clinics to support eye health and through several women’s initiatives including addressing sanitation and female hygiene needs and common nutritive issues such as iron deficiency.

Additional Ocular Support:

Antioxidant Support: Mixed carotenoids, selenium, CoQ10, and lipoic acid protect cells from damage from oxidative stress.

Taurine: An amino acid that is found in high amounts in the retina. A deficiency of taurine is associated with degenerative changes in the photoreceptors of the eye [16}.

Bilberry extract: the anthocyanins in bilberry have powerful antioxidant and anti-inflammatory properties. Recent studies have shown the potential of bilberry to reduce reactive oxygen species threatening neuroreceptors to assist in maintaining normal visual function [17]. The extract also exhibits positive effects on vascular function in ways that may support retinal health [18].

Biologically active B-vitamins: including L-methylfolate, methylcobalamin (B-12), riboflavin 5’ phosphate, and pyridoxal 5’ phosphate. Folate and B-12 support the maintenance of normal homocysteine levels. Hyperhomocysteinemia is a risk factor for impaired ocular function [19].

Vitamin D-3: low serum vitamin D levels are associated with many health concerns, including ocular function and studies have found associations between low vitamin D intake as well as low vitamin D serum status and a higher incidence of advanced age-related macular degeneration [20,21].

Source Materials: Thiamine mononitrate, niacinamide, pyridoxine HCl, pyridoxal 5’ phosphate, L-methylfolate, biotin, pantothenic acid, taurine, and alpha lipoic acid: synthetic. Natural mixed carotenoids: carrot and marigold extracts. Ascorbic acid: corn sorbitol. Vitamin D3: lanolin from sheep’s wool. Vitamin E succinate: purified soy oil. Riboflavin 5 phosphate and methylcobalamin: dextrose fermentation. Minerals are mined. Chelating agents include: glycine (synthetic), citric acid (corn fermentation), methionine (synthetic), glucuronic acid (synthetic). Lemon bioflavonoids: lemon. CoQ10: fermentation. Lutein and zeaxanthin: marigold extract. Bilberry extract: Vaccinium myrtillus fruit. L-leucine: fermentation of sugar. Cellulose for capsules is derived from softwood tree pulp.

Allergens:  According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.

Recommendations: Three (3) capsules daily with meals, or as directed by a healthcare professional.

Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.




2.Wang JJ, Mitchell P, Cumming RG, Smith W. Visual impairment and nursing home placement in older Australians: The Blue Mountains Eye Study. Ophthalmic Epidemiology. 2003;10(1):3–13.

3.Klein BE, Moss SE, Klein R, et al. Associations of visual function with physical outcomes and limitations 5 years later in an older population: The Beaver Dam Eye Study. Ophthalmology. 2003;110(4):644–650. 

4.Cruikshanks K, Klein R, Klein B. Sunlight and age-related macular degeneration: The Beaver Dam eye study. Arch Opthalmol. 1993;111(4): 514-518.

5.Quillen D. Common causes of vision loss in elderly patients. Am Fam Physician. 1999 Jul 1;60(1):99-108.

6.Braakhuuis A, Raman R, Vaghefi E. The association between dietary intake of antioxidants and ocular disease. Diseases. 2017; 5:3.

7.AREDS Research Group. The age-related eye disease study (AREDS): the results of the clinical trial. Insight. 2002, Jan-Mar; 27(1): 5-7.

8.AREDS2 Research Group. Lutein/zeaxanthin and omega-3 fatty acids for age-related eye disease study 2 (AREDS2) controlled randomized clinical trial. JAMA. 2013 pub online May 5.

9.Richer S, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the veteran’s LAST study (lutein antioxidant supplementation trial). Optometry. 2004; 75: 216-30.

       10.Li ZY, Tso M, Wang HM, Organisciak DT. Amelioration of photic injury in rat retina by ascorbic acid: A            histopathologic study. Investig Ophthalmol Vis Sci. 1985;26: 1589-1598.

11.Aoki A, Inoue M, Nguyen E. Dietary n-3 fatty acid, alpha-tocopherol, zinc, vitamin D, vitamin C, and beta carotene are associated with age-related macular degeneration in Japan. Sci Rep. 2016;6: 20723.

12.Singh U, Devaraj S, Jialal I. Vitamin E, oxidative stress and inflammation. Annu Rev Nutr. 2005;25: 151-174.

13.Newsome DA. A randomized, prospective, placebo-controlled clinical trial of a novel zinc-monocysteine compound in age-related macular degeneration. Curr Eye Res. 2008;33: 591-598.

14.Ma L, Liu R, Du JH, et al. Lutein, zeaxanthin, and meso-zeaxanthin supplementation associated with macular pigment optical density. Nutrients. 2016 Jul; 8(7): 426.

15.Stringham J, Stringham N, O’Brien K. Macular carotenoid supplementation improves visual performance, sleep quality, and adverse physical symptoms in those with high screen time exposure. MDPI. 2017 Jun 29.

16.Ripps H, Shen W. Review: taurine: a ‘very essential” amino acid. Mol Vis. 2012; 18:2673-2686.

17.Osada H, Okamoto T, Kawashima H,et al. Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina. PLoS One. 2017 Jun 1;12(6).

18.Kim J, Kim CS, Lee YM, et al. Vaccinium myrtillus extract prevents or delays the onset of diabetes-induced blood-retinal barrier breakdown. Int J Food Sci Nutr. 2015 Mar; 66(2).

19.Ajith TA, Rainimenon. Homocysteine in ocular diseases. Clin Chim Acta. 2015. Oct23;450: 316-21.

20.Merle B, Silver R, Rosner B, Seddon J. Association between vitamin D intake and progression to incident advanced age-related macular degeneration. Invest Ophthalmol Vis Sci. 2017 Sep 1; 58(11): 4569-4578.

21.Kim KL, Park SP. Association between serum vitamin D deficiency and age-related macular degeneration in Koreans: clinical case control pilot study. Medicine (Baltimore). 2018 Aug; 97(33): e11908.


These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

VitalEyes™ Complete Ocular Formula*
Developed by Dr. Richard Luekenga, O.D.
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