The Big One^® with Iron

Product Code: 00518          Capsules per Bottle: 100

Each size 00 vegetarian cellulose capsule contains:

Vitamin D is derived from lanolin. Natural vitamin E is derived from soy oil.
 

Product Description: 

What is The Big One^® with Iron?

The Big One^® with Iron is a high-potency, one-per-day multivitamin/mineral capsule containing key nutrients at optimal levels. Although it provides a strong foundational range of nutrients to fill nutritional gaps in your diet, The Big One^® with Iron can also be combined with additional supplements to further individualize your supplemental regimen. The Big One^® with Iron is recommended for women in their childbearing years, those with low dietary intake of iron, or anyone requiring supplementary iron as determined by a healthcare professional. All three Big One^® formulas contain the highest quality activated nutrients with no non-nutritive additives.

This formula features highly bioavailable, methylated forms of folate (L-methylfolate) and B-12 (methylcobalamin), phosphorylated forms of riboflavin and B-6, chelated minerals, natural mixed carotenoids, natural vitamin E and iron as ferrous bis-glycinate, a well-tolerated, bioavailable form.

How does The Big One^® with Iron Work?

The Big One^® with Iron provides essential vitamins and minerals to maintain good health. Iron is a component of blood hemoglobin, critical for oxygen transport, and myoglobin, the oxygen carrier in muscles. Inorganic iron supplements such as iron sulfate are poorly absorbed and can cause gastric distress [1]. The Big One^® with Iron contains Ferrochel^® chelated iron bis-glycinate (Albion Minerals) for superior absorption, tolerance, and safety [1].

This multivitamin contains a variety of antioxidants with diverse contributions to healthy cellular function and repair. Antioxidants play an important role in the neutralization of oxidative stress, and antioxidant deficiency is a known cause of numerous chronic and degenerative pathologies [2]. Vitamin E (α-tocopherol) is a fat-soluble vitamin with high antioxidant potency, that protects cell membranes [2]. Vitamin C (ascorbic acid) is a water-soluble, antioxidant vitamin that is essential for collagen, carnitine, and neurotransmitter biosynthesis. Vitamin C works synergistically with vitamin E. Vitamin A (beta-carotene) is a fat-soluble and essential nutrient for vision. Vitamin A is converted to retinol, which is required for the proper function of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response [3]. It is also a strong antioxidant and is the best quencher of singlet oxygen [2]. 

Vitamin D-3, cholecalciferol, is the same form of vitamin D that animals make in response to sunlight. Vitamin D deficiency is a common problem, as research on skin health discourages individuals from spending time exposed to sunlight. However, vitamin D is necessary for the maintenance of bone health and calcium homeostasis [4], and deficiency is linked with osteoporotic bone loss, increased bone fractures, autoimmune disease, and neurodegenerative disorders [5]. Vitamin K has been shown to aid in the maintenance of healthy bones by regulating calcium uptake in bone tissue, increasing new bone formation, and reducing bone resorption [6]. Zinc, manganese, and boron also support bone mineralization [7]. Chromium is an essential trace element that plays an important role in carbohydrate and lipid metabolism. Chromium deficiency has been linked to insulin resistance and diabetes, and oral supplementation with chromium has been found to reverse these effects [8]. Studies show chromium may also benefit muscle building [8].

Selenium (Se) is a trace mineral that helps to activate several antioxidant enzymes and is a known immunomodulator, along with vitamins A and D. Selenium is also necessary for proper thyroid function [2]. Iodine is also essential to thyroid health, as it is a necessary element in the synthesis of thyroid hormone [9].

B vitamins contained in this supplement blend; thiamine, riboflavin, niacinamide, B-6, biotin, pantothenic acid, folate, and B-12, are commonly associated with energy production, nervous system maintenance, and cardiovascular health. Thiamine, riboflavin, niacinamide, B-6, biotin, and pantothenic acid are cofactors for enzymes needed for cellular energy production through the metabolism of proteins, carbohydrates, and fats. Thiamine, folate, B-12 are involved in neural development and neurotransmitter synthesis [10]. The type of B-12 contained in this supplement is the activated, naturally occurring form of cobalamin found in food, methylcobalamin. Many supplements contain cyanocobalamin, which is completely synthetic and not as well-retained as the methylcobalamin found in our formula. Methylfolate and B-6 are required for homocysteine metabolism and have been linked to mood improvement [11]. About half of the population cannot properly process the synthetic form of folate (folic acid), so taking a supplement that contains its activated form is a superior choice for increasing the availability of circulating methylfolate. 

What are the Suggested Uses for The Big One^® with Iron?

As a high-potency, one-per-day multivitamin/mineral capsule, The Big One^® with Iron supports: 

• Cellular health: Antioxidants vitamin A, vitamin C, and vitamin E, and selenium reduce oxidative stress by scavenging free radicals that can cause cellular damage.
• Bone health: Vitamin D and vitamin K (especially K-2) maintain calcium homeostasis, allowing calcium absorption from the bloodstream into bones. Zinc, copper, manganese, and boron also support bone mineralization.
• Immune system function: Vitamin A and vitamin D are immunomodulators. Zinc is required for T-lymphocyte activity.
• Energy production: The B vitamins thiamine, riboflavin, niacinamide, B-6, biotin, and pantothenic acid are cofactors for enzymes needed for cellular energy production through the metabolism of proteins, carbohydrates, and fats.
• Nerve health: Thiamine, folate, B-12 are involved in neural development and neurotransmitter synthesis.
• Cardiovascular health: Methylfolate and B-6 are required for homocysteine metabolism. Thiamin is necessary for the synthesis of D-ribose. High serum vitamin E levels have been associated with cardiovascular health.
• Glucose metabolism: Chromium and vanadium support normal insulin function and glycemic control.
• Thyroid health: Iodine is a precursor in the formation of thyroid hormones.

The Big One^® with Iron provides a solid framework for further individualized supplementation. Combine it with any Metabolic Maintenance calcium and magnesium formula, additional antioxidants, CoQ10, and/or Omega 3s.  

Source Materials: Vitamin A palmitate, vitamin K-1, thiamine mononitrate, niacinamide, pyridoxal 5 phosphate, L-methylfolate, biotin, and pantothenic acid: synthetic. Natural mixed carotenoids: carrot and marigold extracts. Ascorbic acid: corn sorbitol. Ascorbyl palmitate: ascorbic acid from corn and palmitic acid from palm oil. Vitamin D3: lanolin from sheep’s wool. Vitamin E succinate and mixed tocopherols: purified soy oil. Vitamin K-2 M7: soy fermentation (soy removed). Riboflavin 5 phosphate and methylcobalamin: dextrose fermentation. Betaine HCl: sugar beets. Minerals are mined. Chelating agents include: glycine (synthetic), citric acid (corn fermentation), methionine (synthetic), glucuronic acid (synthetic). Cellulose for capsules is derived from softwood tree pulp. There is no detectable GM material present.

Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.

Recommendations: One (1) capsule daily with a meal, or as directed by a healthcare professional.

Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement. Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of the reach of children. In case of an accidental overdose, call a doctor or poison control center immediately.

References:

1. Ashmead HD. The absorption and metabolism of iron amino acid chelate. Arch Latinoam Nutr 2001;1(Suppl 1):13-21.
2. Pham-Huy, Lien Ai, Hua He, and Chuong Pham-Huy. "Free radicals, antioxidants in disease and health." International journal of biomedical science: IJBS 4.2 (2008): 89.
3. National Center for Biotechnology Information. PubChem Compound Database; CID=445354, https://pubchem.ncbi.nlm.nih.gov/compound/445354 (accessed Oct. 19, 2018).
4. Armas, Laura AG, Bruce W. Hollis, and Robert P. Heaney. "Vitamin D2 is much less effective than vitamin D3 in humans." The Journal of Clinical Endocrinology & Metabolism 89.11 (2004): 5387-5391.
5. Tang, Benjamin MP, et al. "Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis." The Lancet 370.9588 (2007): 657-666.
6. Kalkwarf, Heidi J., et al. "Vitamin K, bone turnover, and bone mass in girls." The American journal of clinical nutrition 80.4 (2004): 1075-1080.
7. Reid, Ian R., Mark J. Bolland, and Andrew Grey. "Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis." The Lancet 383.9912 (2014): 146-155.
8. National Center for Biotechnology Information. PubChem Compound Database; CID=23976, https://pubchem.ncbi.nlm.nih.gov/compound/23976 (accessed Oct. 19, 2018).
9. Markou, K., et al. "Iodine-induced hypothyroidism." Thyroid 11.5 (2001): 501-510.
10. Selhub, Jacob, et al. "B vitamins, homocysteine, and neurocognitive function in the elderly–." The American journal of clinical nutrition 71.2 (2000): 614S-620S.
11. Bottiglieri, Teodoro, et al. "Homocysteine, folate, methylation, and monoamine metabolism in depression." Journal of Neurology, Neurosurgery & Psychiatry 69.2 (2000): 228-232.