L-Phenylalanine is an essential amino acid that converts to tyrosine. It follows the catecholamine pathway and is a precursor to thyroid hormone. Phenylalanine—>Tyrosine—>Norepinephrine —>Epinephrine L-Phenylalanine helps support the normal production of mood-elevating chemicals in the brain such as dopamine and norepinephrine. D-Phenylalanine helps to naturally reduce pain signals in the nervous system. The combination of the two forms may help support normal mood and address physical discomforts. It should not be used with MAO inhibitors or tricyclic antidepressants, or by patients who have PKU, or hypertension. *
Product Code: 00114 Capsules per Bottle: 60
Each size 000 vegetarian cellulose capsule contains:
Vitamin B-6 (as Pyridoxine HCI)
Other ingredients: L-leucine
Description: L-Phenylalanine is an essential amino acid that is converted to tyrosine. It follows the catecholamine pathway and is a precursor to thyroid hormone. L-Phenylalanine helps support the normal production of mood-elevating chemicals in the brain such as dopamine and norepinephrine. D-Phenylalanine helps to naturally reduce pain signals in the nervous system. The combination of the two forms may help support normal mood and address physical discomforts. It should not be used with MAO inhibitors or tricyclic antidepressants, or by patients who have PKU, or hypertension.
Uses: Insufficient activity of the neurotransmitters serotonin and norepinephrine is a central element of the model of depression most widely held by neurobiologists today. The synthesis of most neurotransmitters is controlled within the brain, and for some neurotransmitters, the amount of biochemical precursors present in the brain can influence their rate of synthesis . As phenylalanine is a precursor for neurotransmitter production, it can support the maintenance of a balanced mood.
Natural forms of phenylalanine is associated with a variety of brain functions. One of those pathways leads to pain relief systems throughout the body. When signals of pain from a particular sector of the body reach the brain, hormones are released and directed to the given point of trauma. The anesthetic power of this endorphine system, involving products of phenylalanine, extends into the realm of chronic pain as well. DL-Phenylalanine seem to modulate the signals for chronic pain only. Studies demonstrate that DL-Phenylalanine does not interfere with or mask the triggering system in the brain for acute, short-term pain.
This effect of DL-Phenylalanine may be mediated, at least in part, by up-regulation of the ‘endogenous analgesia system’ (EAS). When stimulated by chronic pain, the EAS suppresses activation of second-order pain-receptive neurons in the dorsal horn, and thereby alleviates pain . Since serotonin and enkephalins are key neurotransmitters in the EAS, it is reasonable to predict that supplements which promote serotonin activity (such as D-phenylalanine, an enkephalinase inhibitor) would also potentiate EAS-mediated analgesia.
Furthermore, studies have shown that DL-Phenylalanine binds to glutamate AMPA receptors, which improve the communication between synapses in the brain . This has the effect of increasing memory speed and learning ability, promoting increased mental energy and focus.
Source Materials: D,L-Phenylalanine is synthesized from L-phenylalanine (from fermentation) and acetic acid. Pyridoxine HCl is synthetic. L-leucine is made by fermentation. Cellulose for capsules is derived from softwood tree pulp. All ingredients are vegan and non-GMO.
Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, fish, shellfish, peanuts, tree nuts.
Recommendations: Use as directed by a healthcare professional.
Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.
- Meyers, Stephen. "Use of neurotransmitter precursors for treatment of depression." Alternative Medicine Review 5.1 (2000): 64-71.
- Morris, Ritchi. “DLPA: Natural Relief for Chronic Pain.” Alternative (Complementary) Medicine Topics. April 10, 2013 www.afpafitness.com/research-articles/dlpa-natural-relief-for-chronic-pain
- Russell, A. L., and M. F. McCarty. "DL-phenylalanine markedly potentiates opiate analgesia–an example of nutrient/pharmaceutical up-regulation of the endogenous analgesia system." Medical hypotheses 55.4 (2000): 283-288.
- Hill, Ronald, et al. “Structure−Activity Studies for α-Amino -3-hydroxy -5-methyl -4-isoxazolepropanoic Acid Receptors: Acidic Hydroxyphenylalanines.” Journal of Medicinal Chemistry 1997 40 (20), 3182-3191.
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.