SAMe Plus Cofactors

60 CAPS | 200 MG Product No. 00156

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SAMe is a critical methyl donor for several important reactions in the body including the formation of healthy levels of neurotransmitters. Other nutrients contribute to the cycle of methylation reactions as well. We offer SAMe with its nutrient cofactors to provide an easy-to-take product to support methylation processes in the body.

  • Promotes the conversion of homocysteine back to SAMe*
  • Nourishes healthy neurotransmitter formation*
  • Supports balanced mood*


*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

SAMe + Cofactors 200 mg


Product Code: 00156            Capsules per Bottle: 60


Each size 00 acid-resistant vegetarian cellulose and gellan gum capsule contains:


Vitamin B-6 (as Pyridoxal 5 Phosphate)

2 mg

Folate (200 mcg from L-5-Methylfolate, glucosamine salt)

333 mcg DFE

Vitamin B-12 (as Methylcobalamin)

500 mcg

Calcium (as Calcium Citrate)

20 mg

Magnesium (as Magnesium Citrate)

20 mg

SAMe (from 444 mg S-Adenosyl-methionine-disulfate-p- toluensulfonate, calcium chloride, calcium oxide)

200 mg

Other ingredients: L-leucine, (capsule contains gallen gum.)


Description:  SAMe, a metabolite of the amino acid L-methionine, is present in all cells of the body. It plays a crucial biochemical role as a methyl donor in the synthesis of neurotransmitters, nucleic acids, phospholipids and proteins. This formula also provides cofactors needed for SAMe metabolism: B-6, B-12, folate, and magnesium.


Uses: 1) Mood and brain health. SAMe has been extensively researched for its ability to promote positive mood and emotional balance. SAMe-dependent methylation reactions are vital for the synthesis monoamine neurotransmitters: dopamine, serotonin, epinephrine, and norepinephrine. The networks of neurons that utilize monoamine neurotransmitters are involved in the regulation of cognitive processes such as emotion, arousal, and certain types of memory. SAMe is also needed for phosphatidylcholine production which is vital for cell membrane fluidity and central nervous system function.

2) Joint health. SAMe has been shown to promote joint comfort. Evidence suggests SAMe increases production of proteoglycans- proteins found in connective tissue. SAMe may also reduce inflammatory mediators.

3) Liver health. SAMe methyl groups contribute to the fluidity of liver lipid membranes. Methylation is an important Phase II detox pathway. SAMe has been shown to improve liver function as measured by standard liver tests and to increase hepatic glutathione levels.


Vitamins B-6, B-12 and folate are necessary cofactors in the methylation cycle, allowing the reactions required for SAMe’s benefits. They are provided in this formula in their bio-active forms: pyridoxal 5 phosphate, methylcobalamin, and L-methylfolate. Magnesium is a cofactor for neurotransmitter synthesis and transmission.


Acid-resistant capsules protect SAMe from the low pH of the stomach and deliver it to the small intestine where it is absorbed. Metabolic Maintenance uses SAMe stabilized with calcium made by Gnosis-Bio in Italy. It does not require refrigeration or coatings.


Source Materials: SAMe, methylcobalamin and L-leucine are made by fermentation. Pyridoxal 5 phosphate and L-methylfolate are made by chemical synthesis. Calcium and magnesium are mined


minerals. Citric acid (for citrates) is made by fermentation of corn sugar. Cellulose for capsules is derived from softwood tree pulp. Gellan gum for acid resistant capsules is made by fermentation with Pseudomonas elodea. All ingredients are vegan and non-GMO.


Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.


Recommendations: One to two (1-2) capsules daily, between meals, or as directed by a healthcare professional.


Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement. If you suffer from bipolar (manic) depression, do not use this product.



These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

SAMe Plus Cofactors
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