Product Code: 00634 Capsules per Bottle: 180
Each size 3 vegetarian cellulose capsule contains:
Other ingredients: vegetarian cellulose capsule
What is Melatonin?
The naturally occurring pineal hormone, melatonin, is involved in the circadian regulation and facilitation of sleep, the inhibition of cellular mutation, and the enhancement of immune function .
How does Melatonin Work?
Melatonin is a hormone that is mainly produced by the pineal gland during hours of darkness to help regulate the "body clock” that controls when you're awake and when your body is ready for sleep. This clock typically follows a 24-hour cycle called the circadian rhythm. The rhythm affects how every cell, tissue, and organ works . Although melatonin is known as a neurohormone, which we typically associate with the brain, it has been found in all kingdoms of life, including both vertebrate and invertebrate animals, bacteria, fungi, algae, and plants. And, in all kingdoms melatonin production requires an intake of the aromatic amino acid L-tryptophan, and is synthesized from serotonin . Supplementing with melatonin alone will not change circulating levels of serotonin, or affect mood, but low levels of serotonin could be a cause for poor melatonin production and consequential difficulty sleeping . This is one probable link between sleep disorders and depression, drug addiction, and other serotonin-related pathologies .
Naturally, sufficient levels of circulating melatonin should spike at night to help us fall and stay asleep, but as we age, we tend to produce less and less melatonin . This may be the reason new sleep difficulties often arise as we advance into our later years. It is also the reason that melatonin supplements should be taken in the evenings so that the highest levels of circulating melatonin occur when you are ready to bring on sleep, mimicking the young, healthy body’s natural cycles.
Outside of the pineal gland, gastrointestinal tissue contains the highest concentrations of naturally occurring melatonin . There, melatonin has been demonstrated to prevent ulcerations of gastrointestinal mucosa by an antioxidant action, reduce the secretion of hydrochloric acid, stimulate the immune system, foster epithelial regeneration, and increase microcirculation .
Several studies have shown that melatonin reduces chronic and acute inflammation, and as a consequence, melatonin improves the clinical course of illnesses which have an inflammatory etiology . Melatonin also has immunomodulatory activity, regulating cytokine production of immunocompetent cells, reducing adhesion molecules and pro-inflammatory cytokines, and modifying serum inflammatory parameters.
Melatonin is also both a direct and indirect antioxidant, scavenging free radicals, stimulating antioxidant enzymes, enhancing the activities of other antioxidants or protecting other antioxidant enzymes from oxidative damage .
What is the Suggested Use for Melatonin?
- Promotes restorative sleep. When taken in the evenings, a small dose of melatonin can boost the natural release of this hormone, encouraging the onset of sleep and helping to regulate the circadian rhythm.
- Supports healthy blood pressure. As the circadian clock is involved in autonomic cardiovascular regulation, nighttime melatonin intake has also been shown to help regulate blood pressure .
- Aids in immunity and tissue health. As an immunomodulator, anti-inflammatory, and antioxidant, melatonin exerts a variety of protective effects on your cells and tissues.
Source Materials: Melatonin is made by chemical synthesis. Cellulose for capsules is derived from softwood tree pulp. All ingredients are vegan and non-GMO.
Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, fish, shellfish, peanuts, tree nuts.
Recommendations: Use as directed by a healthcare professional.
Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.
- Blask, David E. "Melatonin, sleep disturbance and cancer risk." Sleep medicine reviews 13.4 (2009): 257-264.
- National Institutes of Health. Sleep Deprivation and Deficiency Website. Accessed Dec 10, 2018. https://www.nhlbi.nih.gov/health-topics/sleep-deprivation-and-deficiency
- Erland, Lauren AE, and Praveen K. Saxena. "Melatonin natural health products and supplements: presence of serotonin and significant variability of melatonin content." Journal of Clinical Sleep Medicine 13.02 (2017): 275-281.
- Hardeland, Rüdiger. "Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction." The Scientific World Journal 2012 (2012).
- Sack, Robert L., et al. "Human melatonin production decreases with age." Journal of pineal research 3.4 (1986): 379-388.
- Esposito, Emanuela, and Salvatore Cuzzocrea. "Antiinflammatory activity of melatonin in central nervous system." Current neuropharmacology 8.3 (2010): 228-242.
- Bubenik, George A. "Gastrointestinal melatonin: localization, function, and clinical relevance." Digestive diseases and sciences 47.10 (2002): 2336-2348.
- Scheer, Frank AJL, et al. "Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension."Hypertension 43.2 (2004): 192-197.
* These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.