Our Metabolic Detox® capsules combine the active ingredient silymarin (isolated from the classic liver-supporting botanical, milk thistle), as well as naturally occurring thiol antioxidants, N-acetyl-cysteine (NAC) and alpha lipoic acid (ALA). Silymarin expresses membrane-stabilizing and antioxidant activities, promotes regeneration of the liver, reduces inflammatory reactions, and inhibits fibrogenesis. NAC inhibits hepatocyte apoptosis and oxidative stress pathways and is a precursor for (and regulator of) glutathione synthesis. ALA is an amphipathic, metabolic antioxidant and detoxification agent, and decreases lipogenesis in the liver.*
- Supports liver function*
- Provides antioxidant protection*
- Supports the production of glutathione*
- Supports Phase I and Phase II detoxification*
*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Metabolic Detox® Capsules
Product Code: 00217 Capsules per Bottle: 60
Each size 00 vegetarian cellulose capsule contains:
(from Milk Thistle Seed Extract, Silybum marianum, standardized to 80% silymarin)
Alpha Lipoic Acid
Other ingredients: L-leucine.
Description: Metabolic Detox® is formulated to support Phase I detoxification (chemically transforming lipid soluble compounds into water soluble compounds in preparation for detoxification) and Phase II detoxification (modifying Phase I products to increase their solubility and reduce their toxicity) while offering protection from oxidative damage. This product combines the active ingredient silymarin (from the classic liver botanical milk thistle) with antioxidants N-acetyl-cysteine (NAC) and alpha lipoic acid (ALA).
Uses: Silymarin is an extract of the milk thistle (Silybum marianum), the dietary supplement taken most frequently by patients to maintain healthy liver function . Silymarin is a herbal product and no health hazards or side effects have been documented in conjunction with proper administration . Silymarin expresses membrane-stabilizing and antioxidant activities, promotes hepatocyte regeneration, reduces inflammatory reactions, and inhibits fibrogenesis . Silymarin increases protein synthesis in hepatocytes by stimulating RNA polymerase I activity . Silymarin also exhibits fairly specific effects on cell-regulating mechanisms, including, but not limited to, scavenging of reactive oxygen species, indicating a potential for this extract to reduce toxic effects of other drugs .
Apoptotic cell death of hepatocytes has emerged as a fundamental component of virtually all acute and chronic liver diseases . Silymarin modulates imbalance between cell survival and apoptosis through interference with the expressions of cell cycle regulators and proteins involved in apoptosis . Antioxidants might aid in the prevention fulminant hepatic failure by interfering with the deadly cascade . Alpha lipoic acid (ALA) and N-acetyl-cysteine (NAC) are both naturally occurring thiol antioxidants with diverse biological roles.
ALA has been described as a potent biological antioxidant and detoxification agent, it has been used to improve age-associated cardiovascular, cognitive, and neuromuscular deficits, and has been implicated as a modulator of various inflammatory signaling pathways . ALA is a naturally occurring thiol antioxidant, and decreases hepatic lipogenesis . As a “metabolic antioxidant”, ALA is accepted by human cells as substrate and is reduced to dihydrolipoic acid (DHLA). DHLA is not destroyed by quenching free radicals, but rather can be recycled from ALA. Moreover, ALA and DHLA are amphipathic molecules and may act as antioxidants both in hydrophilic and lipophilic environments . Dietary supplementation
with ALA has been associated with positive effects in a variety of model conditions associated with an imbalance of redox status, including hepatic disorders .
N-acetyl-cysteine (NAC) consistently inhibits apoptosis and interferes with oxidative stress pathways induced by a variety of stimuli . NAC is also a precursor for glutathione synthesis and plays a role in its regulation. Glutathione is essential for a healthy liver for a variety of reasons. Among other roles, glutathione scavenges free radicals and other reactive oxygen species; it reacts with various electrophiles, physiological metabolites (e.g., estrogen, melanins, prostaglandins, and leukotrienes), and xenobiotics (e.g., bromobenzene and acetaminophen) to form mercapturates; it regulates cellular lipid, glucose, and amino acid utilization; and aids in the removal of formaldehyde . Silymarin is also known to increase hepatic glutathione and may also contribute to the antioxidant defense of the liver .
Source Materials: Silymarin is extracted from the seeds of milk thistle (Silybum marianum). Alpha lipoic acid: chemical synthesis. NAC: feathers. Cellulose for capsules is derived from softwood tree pulp. All ingredients are non-GMO.
Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, fish, shellfish, peanuts, tree nuts.
Recommendations: Use as directed by a healthcare professional.
Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.
- Fehér, János, and Gabriella Lengyel. "Silymarin in the prevention and treatment of liver diseases and primary liver cancer." Current pharmaceutical biotechnology 13.1 (2012): 210-217.
- Shaker, E., H. Mahmoud, and S. Mnaa. "Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage." Food and Chemical Toxicology 48.3 (2010): 803-806.
- Vargas-Mendoza, Nancy, et al. "Hepatoprotective effect of silymarin." World journal of hepatology 6.3 (2014): 144.
- San-Miguel, B., et al. "N-acetyl-cysteine protects liver from apoptotic death in an animal model of fulminant hepatic failure." Apoptosis 11.11 (2006): 1945-1957.
- Shay, Kate Petersen, et al. "Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential." Biochimica et Biophysica Acta (BBA)-General Subjects 1790.10 (2009): 1149-1160.
- Park, Keun‐Gyu, et al. "Alpha‐lipoic acid decreases hepatic lipogenesis through adenosine monophosphate‐activated protein kinase (AMPK)‐dependent and AMPK‐independent pathways." Hepatology 48.5 (2008): 1477-1486.
- Moini, Hadi, Lester Packer, and Nils-Erik L. Saris. "Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic acid." Toxicology and applied pharmacology 182.1 (2002): 84-90.
- Wu, Guoyao, et al. "Glutathione metabolism and its implications for health." The Journal of nutrition 134.3 (2004): 489-492.
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.