Product Code: 00144             Capsules per Bottle: 60

Each size 0 vegetarian cellulose capsule contains:

  Other ingredients: L-leucine

Description: L-Phenylalanine is an essential amino acid that is converted to tyrosine. It follows the catecholamine pathway and is a precursor to thyroid hormone. L-Phenylalanine helps support the normal production of mood-elevating chemicals in the brain such as dopamine and norepinephrine.  The L form of phenylalanine may help support normal mood and attention. It should not be used with MAO inhibitors or tricyclic antidepressants, or by patients who have PKU, or hypertension.

Uses: Insufficient activity of the neurotransmitters serotonin and norepinephrine is a central element of the model of depression most widely held by neurobiologists today. The synthesis of most neurotransmitters is controlled within the brain, and for some neurotransmitters, the amount of biochemical precursors present in the brain can influence their rate of synthesis [1]. Reduced serotonin and/or catecholamine neurotransmission increases vulnerability to lowered mood. As L-phenylalanine is a precursor for neurotransmitter production, its supplementation can support the maintenance of a balanced mood [2].

There is a substantial body of literature linking the B vitamins with mood. Vitamin B-6 intake has also been positively associated with memory performance. Research indicates vitamin B-6 may act as a catalyzing cofactor in methylation in the central nervous system, thereby influencing cognitive function and mood [3].

Source Materials: Pyridoxine HCl is synthetic. L-leucine is made by fermentation. Cellulose for capsules is derived from softwood tree pulp. All ingredients are vegan and non-GMO.

Allergens:  According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, fish, shellfish, peanuts, tree nuts.

Recommendations: Use as directed by a healthcare professional.

Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.

References:

1. Meyers, Stephen. "Use of neurotransmitter precursors for treatment of depression." Alternative Medicine Review 5.1 (2000): 64-71.
2. Leyton, M., et al. "Effects on mood of acute phenylalanine/tyrosine depletion in healthy women."Neuropsychopharmacology 22.1 (2000): 52-63.

3. Bryan, Janet, Eva Calvaresi, and Donna Hughes. "Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages." The Journal of nutrition 132.6 (2002): 1345-1356.