This workhorse nutrient performs numerous vital functions, including supporting wound healing and the secretion of key hormones such as insulin and glucagon. Arginine is a valuable precursor to nitric oxide which promotes vasodilation and cardiovascular health. It also helps maintain normal systolic and diastolic blood pressure and total and LDL cholesterol. *
Product Code: 00122 Capsules per Bottle: 100
Each size 0 vegetarian cellulose capsule contains:
Description: This workhorse nutrient performs numerous vital functions, including supporting the body’s normal wound healing and the secretion of key hormones such as insulin and glucagon. L-Arginine is a valuable precursor to nitric oxide which promotes vasodilation and cardiovascular health. It also helps maintain normal systolic and diastolic blood pressure and total and LDL cholesterol.
Uses: Though arginine is considered a nonessential amino acid, it becomes “conditionally essential” as a limiting substrate under stress conditions . The identification of nitric oxide (NO) as a product of the metabolism of L-arginine through the NO synthase pathway has opened up a significant amount of recent research. Nitric oxide, produced from L-arginine by NO synthase in virtually all mammalian cells, plays a role in myriad cellular processes; one of which is wound healing. Arginine has been shown to promote wound strength and collagen deposition in the healing of acute wounds . This effect is likely supported by NO’s participation in the upregulation of cell signaling and protein synthesis, and arginine’s contribution to cell proliferation through its metabolism to ornithine and to polyamines .
L-Arginine supplementation has been shown to support cardiovascular function through contributing to processes related to cholesterol balance [2,3], healthy blood flow , normal blood pressure , and the promotion of fat metabolism over fat synthesis [5,6]. In clinical studies, L-arginine supplementation has been associated with the attenuation of endothelial dysfunction associated with high cholesterol and coronary heart disease, and acutely lowered blood pressure in normotensive and in salt-sensitive hypertensive individuals . Oral supplementation of L-arginine in other clinical trials also demonstrated an effect of increased exercise-induced blood-flow, mediated by NO . Endothelial production of NO, specifically, is a key element in many of the processes associated with the development of atherosclerosis . Therefore, l-arginine supplementation, and its consequential augmentation of NO production, is a means to support vascular health in a variety of ways.
L-Arginine plays an important role in fat metabolism. Nitric oxide stimulates the oxidation of energy substrates (including fatty acids and glucose) throughout the body . The tissues in which this process takes place include, but are not limited to, adipocytes, liver, skeletal muscle, and heart . Current evidence shows that physiological levels of arginine and NO promote fat oxidation and decrease fat synthesis in a tissue-specific manner; suggesting arginine may regulate intracellular protein turnover, favoring protein deposition . Dietary arginine supplementation may also increase insulin sensitivity and amplify its signaling mechanisms on net protein synthesis . Thus, arginine supplementation may play a role in the regulation and repartitioning of dietary energy to favor muscle over fat synthesis in adults .
Source Materials: Cellulose for capsules is derived from softwood tree pulp. All ingredients are vegan and non-GMO.
Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, fish, shellfish, peanuts, tree nuts.
Recommendations: Use as directed by a healthcare professional.
Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.
- Stechmiller, Joyce K., Beverly Childress, and Linda Cowan. "Arginine supplementation and wound healing." Nutrition in Clinical Practice 20.1 (2005): 52-61.
- Siani, Alfonso, et al. "Blood pressure and metabolic changes during dietary L-arginine supplementation in humans."American journal of hypertension 13.5 (2000): 547-551.
- Preli, Robert B., Karen Potvin Klein, and David M. Herrington. "Vascular effects of dietary L-arginine supplementation."Atherosclerosis 162.1 (2002): 1-15.
- Hambrecht, Rainer, et al. "Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation."Journal of the American College of Cardiology 35.3 (2000): 706-713.
- Fu, Wenjiang J., et al. "Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats." The Journal of Nutrition 135.4 (2005): 714-721.
- Jobgen, Wenjuan, et al. "Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats." The Journal of nutrition (2008): jn-108.
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.