Glucosamine Chondroitin with Hyaluronic Acid

60 CAPS Product No. 00624

$43.00
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We have combined our maximum potency glucosamine chondroitin formula with hyaluronic acid to provide a more complete supplement for maintaining joint health. These three closely related compounds are components of glycoaminoglycans (GAGS) found in articular cartilage. GAGS are vital for cartilage’s resiliency and shock-absorption properties. Hyaluronic acid has been shown to support tissue hydration and joint lubrication.*

  • Provides support for joint comfort and mobility*
  • Supports healthy lubrication and shock absorption*
  • Promotes cartilage synthesis and joint integrity*

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Glucosamine/Chondroitin with HA

 

Product Code: 00624              Capsules per Bottle: 60

 

Each size 000 vegetarian cellulose capsule contains:

 

Glucosamine Sulfate (as 1350 mg of d-Glucosamine Sulfate 2KCI)

1000 mg

Chondroitin Sulfate (as 850 mg of Chondroitin Sulfate Na)

800 mg

Hyaluronic Acid (as Sodium Hyaluronate)

80 mg

Glucosamine sulfate derived from shellfish.

 

Description: We have combined our maximum potency glucosamine chondroitin formula with hyaluronic acid to provide a more complete supplement for maintaining joint health. These three closely related compounds are components of glycoaminoglycans (GAGS) found in naturally occuring articular cartilage matrices and synovial fluid [1].

 

Uses: At least 20 million Americans suffer from osteoarthritis (OA) [2] and many more suffer from non-arthritic joint pain.  OA is the most common form of arthritis and is a major cause of morbidity, activity limitation, physical disability, excess health care utilization, and reduced quality of life, especially in people aged 65 years and older [3]. OA is characterized by progressive structural and metabolic changes in joint tissue, mainly comprising cartilage degradation, subchondral bone sclerosis, and synovial membrane inflammation. As such, OA management plans are designed to relieve pain and maintain joint mobility in daily life over the long term. While medical therapies primarily address the treatment of joint pain with analgesics and anti-inflammatory drugs, these treatments can cause serious, adverse gastrointestinal and cardiovascular events, especially with long term use [2].

 

The dietary supplements glucosamine and chondroitin sulfate have been advocated as safe and effective complementary or alternative options for symptom management for patients with osteoarthritis or cartilage-related joint pain. Chondroitin is a highly hydrophilic, gel forming polysaccharide macromolecule. Its hydrocolloid properties convey much of the compressive resistance of cartilage. Glucosamine is an amino sugar that is a building block for the glycosaminoglycans that are part of the structure of cartilage. Glucosamine sulfate GAGS are vital for the resiliency and shock-absorption properties of cartilage. Glucosamine and chondroitin are considered long-term structure-modifying agents as they have been shown to have a beneficial effect of delaying long-term knee OA cartilage loss [4], in addition to reducing pain, stiffness, functional limitations and joint swelling/effusion [5, 6]. In subjects with knee pain, evidence has been provided to show that glucosamine and chondroitin supplementation is effective for relieving knee pain and improving locomotor functions [7]. Hyaluronic acid has also been shown to support tissue hydration and joint lubrication [1].

 

Source Materials: Glucosamine sulfate is derived from shells of crab and/or shrimp. Chondroitin sulfate is derived from bovine cartilage (BSE-free). Hyaluronic acid is made by fermentation. Cellulose for capsules is derived from softwood tree pulp. All ingredients are non-GMO.

 

 

 

Allergens:  Glucosamine sulfate has been derived from shellfish. According to information provided by our suppliers, these capsules are free of seven of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, fish, peanuts, tree nuts.

 

Recommendations: Use as directed by a healthcare professional.

 

Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.

 

References:

  1. Pavelká, Karel, et al. "Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study." Archives of internal medicine 162.18 (2002): 2113-2123.
  2. Wandel, Simon, et al. "Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis." Bmj 341 (2010): c4675.
  3. Morita, Mitsuhiro, et al. "Efficacy of Chondroitin Sulfate for Painful Knee Osteoarthritis: A One-Year, Randomized, Double-Blind, Multicenter Clinical Study in Japan." Biological and Pharmaceutical Bulletin 41.2 (2018): 163-171.
  4. Raynauld, Jean‐Pierre, et al. "Long‐Term Effects of Glucosamine and Chondroitin Sulfate on the Progression of Structural Changes in Knee Osteoarthritis: Six‐Year Followup Data From the Osteoarthritis Initiative." Arthritis care & research 68.10 (2016): 1560-1566.
  5. Hochberg, Marc C., et al. "Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib." Annals of the rheumatic diseases (2015): annrheumdis-2014.
  6. Zeng, Chao, et al. "Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee." Scientific Reports 5 (2015): 16827.
  7. Kanzaki, Noriyuki, et al. "Glucosamine-containing supplement improves locomotor functions in subjects with knee pain: a randomized, double-blind, placebo-controlled study." Clinical interventions in aging 10 (2015): 1743.

 

 

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Glucosamine Chondroitin with Hyaluronic Acid
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