Product Code: 00705 Capsules per Bottle: 60
Each size 00 vegetarian cellulose capsules contains:
Proprietary Enzyme Blend:
Dipeptidyl Peptidase (DPP-IV) (Protease I, Protease II, Protease III, Protease IV, Protease V), Amylase I, Amylase II, Glucoamylase, Cellulase, Hemicellulase, Alpha Galactosidase, Xylanase, Lactase, and Lipase.
Other Ingredients: tapioca maltodextrin.
Description: GluDaZyme™ is a comprehensive digestive enzyme that helps to digest gluten, casein, complex carbohydrates, sugars, lactose, and fats. GluDaZyme™ contains a proprietary dipeptidyl peptidase IV (DPP-IV) enzyme blend. It is specially formulated to help support healthy digestion processes and normal response to gluten and casein peptides. GluDaZyme™ also aids in normal digestion for severe food sensitivities and helps mitigate repercussions of cross-contamination.
Uses: Eating provokes the secretion of multiple gastrointestinal hormones involved in the regulation of gut motility, secretion of gastric acid and pancreatic enzymes, gallbladder contraction, and nutrient absorption. Gut hormones also facilitate the disposal of absorbed glucose through the stimulation of insulin secretion from the endocrine pancreas . Some conditions, such as dairy and gluten intolerance, are characterized by an insufficient production of these digestive enzymes. Supplementing some of these enzymes may optimize digestion and minimize the impact of certain proteins, fats, and carbohydrates, thereby enhancing nutrient availability.
Dipeptidyl peptidase IV (DPP-IV) is a unique multifunctional type II transmembrane glycoprotein that acts as a receptor, binding protein, and proteolytic enzyme. DPP-IV is widely distributed in mammalian tissues, and a high level of DPP-IV activity is found in intestinal brush border membranes . DPP-IV has shown specific action in the breakdown of gluten, among other proteins .
Proteases, also known as proteolytic enzymes, peptidase or proteinase are secreted naturally by the gut to breakdown dietary protein into smaller, absorbable peptides or amino acids . They also breakdown unwanted bacteria, toxins, and cellular debris, complementing and relieving some roles of the immune system .
Amylase is produced naturally by the serous acinar cells of the parotid and submandibular salivary glands in the human body . It is one of the most abundant salivary proteins and plays numerous roles in digestion as a number of isoenzymes (hence the variety included in our formula). Its primary function in digestion is to hydrolyze large starch molecules into to glucose and maltose for cellular transport and energy metabolism . Glucoamylase, specifically, allows breaks down starch into d-glucose .
Many macromolecules from plant sources, including insoluble plant cell wall polysaccharides (mainly cellulose and hemicelluloses), representing 20–30% of the dietary fiber ingested daily, cannot be broken down by enzymes produced by human cells. Microorganisms living in a healthy gut produce some cellulase and hemicellulase, enzymes that break down these cell wall proteins to release valuable, absorbable nutrients from dietary plant material . Supplementing cellulase and hemicellulase may aid in this process.
Alpha galactosidase is a naturally occuring human lysosomal glycosidase responsible for the hydrolysis of terminal a-galactosidic linkages in various glycolipids . Xylanases are glycosidases not produced naturally by human cells, but are secreted by beneficial microorganisms in a healthy human gut . Both glycosidases also aid in cellular breakdown, and are especially beneficial to human digestion of plant material.
Lactose is the disaccharide found in milk and dairy products and absorption of lactose requires enzymatic lactase activity in the small intestinal brush border . Lactose malabsorption is the incomplete hydrolysis of lactose due to lactase deficiency, which may occur as a primary disorder or secondary to other intestinal diseases, and becomes an increasingly identified and diagnosed condition with age, as lactase production by the gut tends to decline over time . Supplementing lactase may aid in the digestion of dairy and the ease of discomfort that often accompanies malabsorption.
Human lipases are secreted most abundantly by the stomach and the pancreas to aid in the digestion and assimilation of dietary fats . Hepatic, lipoprotein and endothelial lipases are also secreted for the metabolism of lipoproteins . Supplementation of these highly hydrophobic enzymes may aid in the digestion of dietary fats, and the absorption of valuable nutrients that are otherwise sequestered by lipid globules.
Source Materials: Cellulose for capsules is derived from softwood tree pulp. All ingredients are vegan and non-GMO.
Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, fish, shellfish, peanuts, tree nuts.
Recommendations: Use as directed by a healthcare professional.
Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.
Detel, Dijana, Mladen Peršic, and Jadranka Varljen. "Serum and intestinal dipeptidyl peptidase IV (DPP IV/CD26) activity in children with celiac disease." Journal of pediatric gastroenterology and nutrition 45.1 (2007): 65-70.
Drucker, Daniel J., and Michael A. Nauck. "The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes." The Lancet 368.9548 (2006): 1696-1705.
Ehren, Jennifer, et al. "A food-grade enzyme preparation with modest gluten detoxification properties." PloS one 4.7 (2009): e6313.
Group, Edward. “The Health Benefits of Protease.” Global Healing Center. (2013). https://www.globalhealingcenter.com/natural-health/protease/
Nater, Urs M., et al. "Human salivary alpha-amylase reactivity in a psychosocial stress paradigm." International Journal of Psychophysiology 55.3 (2005): 333-342.
Thivend, P., CHRISTIANE MERCIER, and A. Guilbot. "Determination of starch with glucoamylase." General Carbohydrate Method. 1972. 100-105.
Robert, Céline, and Annick Bernalier‐Donadille. "The cellulolytic microflora of the human colon: evidence of microcrystalline cellulose‐degrading bacteria in methane‐excreting subjects." FEMS microbiology ecology 46.1 (2003): 81-89.
Bishop, David F., et al. "Human alpha-galactosidase A: nucleotide sequence of a cDNA clone encoding the mature enzyme." Proceedings of the National Academy of Sciences83.13 (1986): 4859-4863.
Collins, Tony, Charles Gerday, and Georges Feller. "Xylanases, xylanase families and extremophilic xylanases."FEMS microbiology reviews 29.1 (2005): 3-23.
Usai-Satta, Paolo, et al. "Lactose malabsorption and intolerance: what should be the best clinical management?."World journal of gastrointestinal pharmacology and therapeutics 3.3 (2012): 29.
Mukherjee, Manjari. "Human digestive and metabolic lipases—a brief review." Journal of Molecular Catalysis B: Enzymatic22.5-6 (2003): 369-376.
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.